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Bravo @Joan Crawford that final sentence was quite the flourish

Two instances of fairly short lived PEM earlier this year that I have some notes from. One from physical activity (sitting up and moving around to cut my hair) another from cognitive/sensory (a very loud and chatty visitor). Both followed similar patterns of aching, more fatigue, feeling ill or...

That is fascinating (but also sounds pretty unpleasant!) thanks for explaining @Kitty And thanks for the reading @Snow Leopard much appreciated

For me the thing that changes the most is the underlying trend of how good or bad I am. Then physical or mental triggers are a layer on top of that. Along with all the other changes we have in exactly which set of symptoms or their intensity/duration. I would say there are some differences in...

From another thread but relevant to throwing idea around I think After some reading/listening on what happens at synapses during neural activity.. @Kitty are you thinking there is something happening which means once the neuron fires the channels just stay open so neurotransmitters continue to...

This information has already been posted but it’s relevant to this thread and a bit fragmented when Imwas searching. So to bring it together.. A Press Release from PrecisionLife says First ever confirmation of long COVID genetic associations. This is going to be one of the topics discussed at...

Yeah 163 is part of NetEase which is huge in China. Good to see the article you linked talk about the history and homonyms, there’s very interesting creative and entertaining uses of language on the internet in China. This was linked to the dialling code needed to get online. For a while in the...

I think that’s a really good analogy. It’s a tool. Or rather a range of tools, that when used for the right things by someone who knows what they’re doing can be great. But it is not a magic wand. I know some people still working in tech and doing lots of interesting things with AI/ML. But are...

I was just looking at this one, started off with an okish definition and then quickly goes into just referring to “CFS”. They apparently used the Fukuda criteria which may explain some of this but by the conclusion it seems to reach almost comic levels of misunderstanding

I’m all for us doing whatever we can to remove obstacles to people doing good research, including things which mean they can focus on that research. It would be nice if talented people didn’t have to worry about or make sacrifices and decisions because of things like costs of food, housing or...

“Certified Lifestyle Medicine Physician” I want to see a Doctor not an Instagram Influencer

Long COVID Mechanisms, Microvascular Effects and Evaluation Based on Incidence Aristotle G. Koutsiaris, Kostas Karakousis Abstract Since the initial reports of Long COVID symptoms, numerous pathophysiological mechanisms have been proposed to explain them; nevertheless, no consensus has been...

NICE are looking for lay members for their prioritisation board. This may well be beyond most here but looks interesting More info here scroll down to the bottom to download the job spec and other documents

Time scales are interesting. And it sounds like perhaps there are different systems which work at different rates or timescales at play? Perhaps one with cells or proteins which have a life of hours or days and others at weeks or months. Perhaps these give rise to some of the variations...

Thanks Jonathan. That’s really interesting and given me more to think about and probably read up on. Some other notes I made earlier thinking more about the permutations and variety involved … Does this all happen when a particular receptor antigen from a particular gene or genes is produced or...

Do you think there is some sort of interesting direct antibody interaction with synapses/nerve cells or instead something more mediated through NK cells or complement or something else?

Last night before going to sleep I was thinking more about what could do his at a very basic level. Presumably there would need to be changes in physical, chemical or electrical properties of cells. Of course the question is which and why. But it seems with such a complex and finely...

It was only after trying to get my head around the Ryback paper and finding VDJ recombination that the scale of it started to dawn on me. I’m sure I don’t get it all now but the elegance of that part of the immune system was a wow moment. And it seems that with that range of possible...

I had similar hopes about covid vaccines for some reason, but very different experiences (with both AZ and Pfizer). What is a vaccine, it’s a way of introducing something to the immune system so it can learn about it and respond. For some of us that response was positive for others negative...

Good questions @Creekside something I’ve been finding is just how many different cells have receptors and in different densities and how one signal that is talked about as doing one thing, usually does but sometimes does something different on a different cell… and on it goes. So what would...