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Even if this is complete happenstance it could serve to establish the elements of a patent I described, so university attorneys would not object. Had the paper made replication too easy they might have. I really hope you are right about a second paper with more detail already on the way. I...

I tried to say that I've signed NDAs that seemed reasonable, but I've rejected some that amounted to "yellow-dog contracts", if not fealty. If you are dealing with reasonable and decent people, these agreements are likely to be reasonable. If you are dealing with unreasonable and litigious...

Since the subject of trade secrets has been introduced above, I will say that we should be thankful Ron Davis and Stanford are not treating this as a trade secret. Patents expire, but trade secrets can last forever, unless they are breached, in which case the holder of a trade secret has very...

There are four things important when filing for a patent that may be relevant here: novelty, utility, priority and non-obviousness (if that is a word.) I think the role of this short paper in establishing the first three is clear, if it does what they say. The last factor is that the device...

I don't expect Ron Davis to conceal matters for long, but he has already indicated there are aspects they don't understand. I'm sure you have been careful about making claims you were not ready to back up. I'm also assuming we will see patent applications derived from this work before long...

Just a comment about lack of a complete description of the test equipment. This is typical of initial disclosures of technical advances with significant economic value. I've seen this with patents, trade secrets and non-disclosure agreements in a completely different context. Simply delaying...

Unfortunately, my personal analysis of the history of medicine concluded that progress is more likely to correlate with mortality rates of physicians than patients. Most seem to pass a threshold when they graduate and are licensed, after which their beliefs change little and slowly. Multiple...

This difference in the graph is what we've been looking for, a major difference in response to cellular stress, and I don't mean psychological stress. We've all been reporting variations on such problems since we fell ill, and being misunderstood. This time someone has tried to find a...

I've just skimmed the paper, and find it extremely interesting, and not just for ME/CFS. They are running a provocative test at the cellular level, rather than attempting to wreck the entire patient, as in some tests I've had. Using osmotic stress tallies with widespread experience that...

In one case where I knew the individual quite well, it brought LDLs down after a great deal of aerobic exercising failed. In that case there was a strong suspicion of familial hypercholesterolemia, none of his close relatives had lived past 50. My point here is that in that case there was...

This is the kind of thing I was thinking about. The fact that there was no drop in mortality in patients over 70, but apparently some benefit for patients who are younger and more vigorous, suggests to me this could be an unplanned experiment revealing one of the factors in aging. Loss of muscle...

On the statins issue, I don't have much background, so I'm going to ask others about their experiences. I know several people who benefited from statins, though generally much younger people than over 70s. I've also encountered several people myself who were "treatment intolerant" when given...

I'll chime in here, simply because I once did get into the scrum about PACE. I was willing to admit it might work on some patients, but the number benefiting by my count was about two. The number harmed, by their numbers was zero, but that required defining a new category in which doctors...

In general, I am not a fan of psychedelics, I had too much interaction with the walking wounded from the initial enthusiasm for LSD. I have some wild stories based on direct experience with the people, not the drugs. That said, there is a possibility the entire idea of changing what is going...

What I want to emphasize in connection with this topic is that the people affected are not subject to any of the putative causes of ME/CFS, yet they can take a year or more to recover. There are measurable changes in expression of genes and activation of viral infections, as well as basic...

@Milo Interesting point, but you should check on what they mean by exercise, and how it affects the physiological changes they experience in microgravity. Unless you are really severely affected I'm guessing you use your legs for more than 2 hours a day. At Earth gravity it is really hard to...

There are several factors in this research effort which either match or differentiate problems of astronauts and ME/CFS patients. One strong similarity is orthostatic intolerance due to inactivity. Astronauts show this so strongly on return that some have needed to be carried when first back in...

Another feature of influenza virus is that it is an RNA virus, as are many enteroviruses. These are less stable than DNA viruses. In addition to passing proteins or viral particles between cells we need to consider naked RNA sequences. These are often assumed to be too fragile to have much...

I'm still processing the very idea of multipart viruses, and discovering other subjects about which I know very little. (Yesterday was lost to income tax preparation, which is now behind me. I avoided paying taxes by the simple expedient of losing money.) Quasispecies work to explain defective...

For as long as I have been reading viral research, which is coming up on a decade, there have been some pretty vicious academic fights over the criteria necessary to establish a disease as a viral infection. In the very obscure field of multipart viruses in plants there has recently been an...