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Here's how they define stigma: Its slightly better than what you thought, @Jonathan Edwards. But not much. What has power got to do with stigma? Isn't it about the attitudes of society in general? And what's this about people with power "using" stigma "to bring about labelling, stereotyping...

Here's the fulltext. Thanks, sci-hub! http://sci-hub.tw/10.1080/21641846.2018.1419553

Is it just me who's a bit sceptical about this? There are a few things niggling me. One is that its an observational study, and there might be lots of factors that determine whether or not a mother will use folic acid. The second is that ASD is a low frequency occurrence, so very small...

Yes, I find this offensive too, @Mithriel. Its usually a judgement made by middle class people who've had every advantage in life, and the judgment is levelled against people with difficult lives, and few real choices.

I LOVE this! So apt! 'Bayes' Alchemy' is my new favourite phrase.

This is my experience too at an individual level, @Jonathan Edwards. My CRP levels can be low and I can feel awful, or high and I can feel not bad. So its not the whole story at all. Although when my CRP was really, really high (30+), then it so happens that I have consistently felt absolutely...

Yea, that's seems highish. One paper that did a really reliable assay on a large number of people found that IL6 levels above 4.45 pg/mL were in the 95th percentile. But maybe just not high enough to raise your CRP substantially?

Sure. I'm weird. Its important to say that. I have a lot of immune type symptoms. Flu-like. Lots of burning glands, headaches, feeling overheated. Very fluctuating pattern. If I overdo activity, I get PEM the next day (an exacerbation of all of the symptoms I just described), but I also get some...

Okay, fair point. And maybe I'm clutching at straws here. But I still worry that "fatigue" is a vague descriptor too, like pain. It might have many causes, that differ widely across people. And even PEM, that we think is so specific, might not be. The reason I think this is that I experience PEM...

@Snow Leopard, that's interesting, and I admit to knowing very little about it. But what if there is massive, really massive heterogeneity in patients diagnosed with ME? There could be variable cytokine profiles, but also many cases where cytokines aren't at play at all. What would that...

Fulltext here at latest sci-hub link: http://sci-hub.tw/10.1080/0952813X.2017.1413140 You gotta love scihub:

No, I didn't even know it existed. Looking at the symptom profile, it doesn't seem a good fit for me. Why do you think it might be relevant?

Thanks @zzz, I knew none of this!

No, not really. Just standard antihistamines for allergies, but I don't think that's the same thing, is it? Those have no effect on my symptoms. My CRP is almost always quite raised (between 11 and 30), and there's a lot of accumulated evidence that IL6 plays a causal role in CRP production. So...

Thanks, @MErmaid! Interestingly, this article seems to be focusing on Zantac's histamine-blocking effect, not its IL6 blocking effect.

I don't know really, I don't think I've pushed it to the limit. I couldn't have given you a number before either, my function has always been so variable - most days I'm limited to bed, but there are odd days when I can walk a bit. But even on a good day I'd commonly get this hot prickly...

Hi folks, just updating on this. I've experienced unprecedented good health over the past 9 days, which coincides with taking the Ranitidine. Perhaps - just perhaps - its helping? Its always easy to misattribute, and there's one other thing that might have something to do with my improvement...

So tired of all this talk of human beings as delicate flowers that can't have any bad stuff happening early in life - without becoming permanently messed up. In some way. Usually mental illness, or depression, or "somatic" illness. Its obviously not like that, because prior to the mid 20th...

There were some nice comments here. I enjoyed this one: This article, mentioned in the comments, was worth a read: https://politicalsciencereplication.wordpress.com/2016/01/29/getting-the-idea-of-transparency-all-wrong/. Some powerful bits:

Yes, I found it rather patronising.