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Yea. I read that Elsevier, one of the largest academic publishing houses, turned a bigger profit than Apple last year. It costs Universities thousands upon thousands for their subscriptions, and lots of journals are bundled, you can't pay for them individually. Plus on top of that, there's quite...

@NelliePledge, this is a digression, but have you tried Sominex (which is phenergen, the antihistamine)? I have found it very effective. You can get it over the counter in the UK. My other half is over there at the moment, and always brings me back some. I'd start with a half tablet. A full one...

I wondered this too @adreno, when I was reading Sasha's paper on healthies (the one I described above). Some of the microbiome features they explored were associated with broader individual factors, such as BMI, age and cholesterol levels. So a simpler approach would be to target those (except...

I had a look at this article. Thanks for posting, @Sasha. What struck me was not the individual variability, but rather the consistency in the direction of the key effects. Yes, the magnitude of each effect varies across individuals, but they were always in the same direction. These factors...

I laughed at that at first, then realised on my current meagre food rations, it'd probably only be around 15 prunes.

:rofl::rofl::rofl::rofl::rofl:!!

Thanks, @Andy, and @Esther12. Its good to have this thread as well, I can select articles people suggest and add them to the Science library.

A thought: If a parent of a sick child sent Dr. Crawley an angry letter, I don't think she would be able to use it, not without revealing that the people that are angry at her are her own patients and their families. I think she is building her narrative on the blueprint set out by Simon Wessely...

I have found 5mg to be effective for sleep, but not lower. Of course, I can't know whether that was just coincidence. But that's my experience.

Hi Maria1, love your new avatar! I've found melatontin to be a good sleep aid, but like @Wonko, I can use it only 1 or 2 nights in a row before it stops working for me. I haven't noticed any benefits in any areas other than sleep.

Yea, thank you for not genderising this. There is no need. Plenty of examples on both sides of the gender divide.

Nice point, @large donner (nice to see you ere by the way!)

I expect Wessely probably was pretty smart at Uni. Lots of these apparent idiots are probably technically intelligent. It just goes to show its all about training and standards. A smart person who enters a field with low quality standards will probably just absorb those standards and produce...

Thanks for finding the reference, @TigerLilea

No, what I was describing was not an 'additional heath problem'. Its at the core of my illness. Its part of the consequences of my constantly high levels of inflammation. High levels of inflammation are a well established risk factor for CVD generally, at least when we use cheap, readily...

I have always just assumed this was the case, and that I'd probably die from a cardiovascular event (like many PwMEs, dying doesn't scare me, its living that really freaks me out!!). Tachycardia and heart palpitations are common symptoms for many PwMEs, and my heart rattles away like there's no...

Gosh, @Arnie Pye, that sounds absolutely awful! I don't have the expertise to advise you on this. But I did read that lately, people have been challenging the received wisdom about antibiotic use. It used to be that you were supposed to use the lowest dose possible, and finish the course...

Some key brain studies of MECFS Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study. Nakatomi Y et al. Journal of Nuclear Medicine. 2014 Jun 1;55(6):945-50.

Welcome, @Lidia! The whole conversion disorder business is so nasty and unpleasant. The article was sickening. The way doctors who promote these concepts use weasel words to avoid saying what they really think. These choice lines from Dr. Alex Lehn. Translation: we think it is psychological...

Problems to watch out for in brain studies of CFS Unreliability. Brain methods generally involve performing many thousands of individual comparisons between the group of interest and the control group. This means that there's a much higher chance than usual of obtaining some significant...