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A few years ago, OMF got a $1M donation specifically to be set aside for the metabolic trap so it may be in reference to that. It seems they are unable to design an experiment to test this hypothesis in patients cells and thus are stuck going an awfully long way around to figure out how to...

The study on "hot" brains wasn't altogether convincing with a very small sample size, and probably some discrepancies between the controls and patients. I'm not sure about the neuroinflammation finding/findings. The study is available here.

Cort had a write up on this, which included this interesting note, implying one of the researchers used the supplement. I completely missed that originally.

I have very little interest in the microbiome at this point. It's interesting to see that sphingomyelins and short-chain fatty acids appear again, they were prominent in some previous metablomics studies.

I'd love to see a thorough multi-omics study of the oral microbiome. This is just 2 peptides afaict. The eyes as well. We need to start looking at reservoirs that aren't just the serum and microbiome.

https://salernocenter.com/2020/09/inspiritol-and-covid-19-testing/ Seems to be an herbal formula he's using on a broad range of illness. Not sure COPD and ME/CFS have an underlying pathology. Strange to see those researchers involved. OFC I believe a treatment *could* come from anywhere, even a...

I think I remember this from a few years ago, they were rejected for comorbidities, or didn't fit the criteria. It wasn't like only 27 actually had me/cfs. It sounds like Hanson is really working hard and trying to be smart about things. She's a good person to have in our corner. I really...

Thanks for doing that, it's important to keep track of that study. It would be a shame if they just dissolved it without much fanfare or, more importantly, without replacing it.

You are correct. The follow-up is called the "Extended Big Data Study in Families" And in addition, the OMF website says the SIPS study should include the following, unless they were dropped. I'm also untroubled by the subjective account of most troublesome symptoms. The average fatigue...

I'm afraid the cortisol finding may be a reflection of the high frequency of sleep disturbance noted in this study. https://www.sciencedirect.com/science/article/abs/pii/S0306453004000125 I was unable to find data on total patient sleep time and delayed phased sleep, but I assume that impacts...

I decided a while ago I only get hopeful about things I can read. It's always hopeful behind the scenes and a few years away.

That's a big claim in the title, hopefully the research lives up to it. Many of those components have appeared in me/cfs research over the years - IL-10 is one of the few cytokines that sticks out frequently enough to be a little curious about.

Nice work. If there is a response it is at that specific threshold, 3cmax. I think that was the dosage that came right after the first 2, who had adverse events. I have to admit the proposed explanation went over my head. It seems there can be a significant increase in HR associate with the...

https://www.healthrising.org/blog/2021/09/03/cortene-drug-trial-chronic-fatigue-syndrome/

Thread on the announcement of the trial: https://www.s4me.info/threads/trial-of-ct38-for-me-cfs-by-cortene-inc-big-claims-being-made.2330/page-4

This is the drug CT-38 that was talked about some time ago. There were no controls and it was unblinded, but there was some partial blinding of dosage. Not a fan of the TDSS because it conflates it all together and chances are good at least some natural improvement will occur or there will...

Is there any reason why a g-coupled receptor aa would be unaffected by IVIG or Rituximab? Worth noting his fatigue might fall under what we call mild or very mild by me/cfs standards and was around 75 at the Bell score when he started treatment. That's pretty high tbh, I don't know how many...

The original study finding Activin B biomarker had a significant COI - related to the development of a drug.

Nice of so many people to go on record in the past year, I'll say that.

https://www.europeanreview.org/wp/wp-content/uploads/8519-8536.pdf See table 1 for protein vs HCs. Brought up as I read a post by @Andy about a possible study on salivary peptide fatigue testing in me/cfs. Could this be useful to find a biomarker in me/cfs?