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I can't understand why on earth Paul Garner, whose own public account of his confused experience complicates his objectivity and who is now obviously biased, would be used in this article. It's so suspect. How is he even got involved? I'm really scratching my head over this one. It's not like...

Indeed. I suspect long-covid may become politicized in very extreme ways. I hope I'm wrong about that.

Full article available as pdf. As expected, even with results that contradict their initial hypothesis, the authors manage to contort it all and bring it back to illness attribution and point the finger at health anxiety.

Shocking. I've heard that drug mentioned maybe 50+ times in references to long covid.

Seems pretty sketchy.....the living with "recovery program" is a hodgpodge of online advice with the goal grinding through as many patients as possible. Then either concurrently in a seperate trial or amongst the existing trial will be the drug testing, it's a bit unclear from the wording. I...

My thoughts on the Horning spinal fluid study is it wouldn’t be replication regardless, but isn't high quality enough to be supportive because 1) The unusual control group, and the variable MS group 2) Some highly unusual results 3) The logic Hornig uses to justify the study as suggesting...

In this video, https://www.s4me.info/threads/iimer...ence-week-london-2019.5907/page-4#post-184672 , it appears to show the first 3 individuals results tested show the same pattern before they pooled. Starts around 4:35. If it was replicated, perhaps it's not a stricly auto-immune situation.

Seems very promising. I like that the methods are detailed, so it should be something another group could reproduce. The authors seemed pretty diligent in trying to avoid the possibility of comorbid autoimmune conditions explained in @Andy s video. The effect seems to lose steam after 5-6 days.

Thanks, just a quick thought on the csf study is it uses controls that got csf drawn on "routine testing" so I don't know how great a reference sample they are because that's obviously not routine. Horning's study was included in a meta analyses of MS cytokines and doesn't seem to match up...

One result I've been wondering about recently is the supposed shift in cytokine profile found by Hornig in 2015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465185/ It's important because it was used by the NIH (I don't have a source for this, I am going off memory) to justify only studying...

This seems like the right idea of what would be a useful study on persistent symptoms in covid. The p-values seem pretty high, though, and the differences amongst cytokines relatively low and frequently overlapping, I guess PGDF-BB looks the most likely. I think that cytokines are altered and...

Several responses to the paper.... https://www.mdpi.com/2072-6651/8/11/322/htm Whatever the detection methods are, the results seem common in the general population. Human biomonitoring of multiple mycotoxins in the Belgian population: Results of the BIOMYCO study...

Did she have me/cfs before, though?

These researchers seem to be very specifically drawn as those who are interested in viruses, so it's not surprising that they would float the idea of viral persistance. Nath is basically only interested in studying post-viral me/cfs, hence the intramural entry criteria. MVE has never produced...

2 Studies on post-covid by Avi Nath. Both started before the end of last year and are not me/cfs specific. https://clinicalstudies.info.nih.gov/protocoldetails.aspx?id=000094-N&&query=Observational%20Neurologic%20COVID-19#contacts Neurologic symptoms...

I am totally fine with Linda T's salary, it isn't a volunteer position. She has performed at a high level in fundraising and raised OMF into a well-run organization that spreads across the globe. She gets the researchers the money, and has done so effectively. The website is well run, their...

Not strictly IDO2, but this 2008 paper https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-2-95 identifies TPH2 as a gene of interest TPH2 is responsible for breaking down tryptophan. I have a couple very uncommon snps there (one is 0% but I think that must be a mistake).

I believe there might be use in going to see if it pinged any other epigentic me/cfs studies, but I'm too tired to do that atm.

Histone deacetylase has come up a few times over the past decade. 1) In 2011, Lenny Jason found, in this paper 2) A group at Brussels has set up a study that that will look at HDAC genes under PEM. https://clinicaltrials.gov/ct2/show/NCT04378634 3) One of the more interesing papers, imo, of...

Thanks everyone, I have the v5 as well for 23andme. @Milo I'm not overly trustworthy, but it felt like getting it a plugging it into a data to see it there was an very clear pathogenic mutation was something I wanted to look to try. Ideally a geneticist and lab would get it. I'm not really...