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This has been my experience too! Years of inactivity, then straight back to being in better shape than most of my friends and family who exercise regularly… I’ve abandoned exercise almost entirely due to PEM, but still preform way beyond what would be expected on the 3-4 bike rides I do in a year.

https://x.com/janetdafoe/status/1692442378466914622?s=46&t=f902mg35pswMiAw81BoXmg

Great job, I really appreciate this initiative! I have been daydreaming along the lines of something like this as an objective endpoint for assessing PEM. I have a suggestion (which you already may have discarded in favour of computational efficiency ;)): - On the keyboard side of things...

I believe it was IDO metabolic trap hypothesis that got ditched. The itaconate shunt hypothesis is still on the table from my understanding, and it connects well with Prusty’s work (supposedly). Correct me if I’m wrong!

Yes, the thoroughly proven null hypothesis: ‘babble’

Will anyone following this issue ever believe that Flottorp had not read the protocol? This wording to avoid liability is just so ironic when trying to meddle with the process through closed channels. Also: Befring is possibly the biggest name in health law in Norway time being. She actively...

The answer is usually money when it comes to this disease, but let's hope they're just incredibly confident about the effect size this time!

FDA approved / Investigational / Herbal ?

Sorry, got it mixed up there, my bad. No correlation should still raise some brows, if only.. Wyllers own music therapy study did show a decrease i step count though, no?

Especially since data from other CBT/GET trials suggest a negative correlation between subjective scoring and actual measured activity!

I have a vague hope it's a reference to NICE's surfacing aspirations to school Cochrane in the basics of calculus. NICE: "So, here we have two time series from a repeated maximal grip strength test. The upper one is of patients fulfilling the Oxford criterion only, the lower one is of patients...

It would sure be nice to see an honest attempt at decoupling the effects of negotiation tactics from the actual interventions in these trials. Decision-making is (arguably) one of the more robust disciples within psychology in terms of the potential of setting up actual testable hypotheses, but...

Hard to decide if this is incredibly proactive, or if someone just discovered the search/replace function..

Regarding the lopsided coverage in Khrono, the journalist writing most of the ME-related stuff, Amanda Schei is apparently closely related to this guy: He's been part of a think-tank together with Linn O. Getz (Vogt's PhD supervisor). ....And has of course published an opinion piece on magic...