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  1. Sid

    The nanoneedle salt stress test – too good a clue to leave abandoned on the lab bench?

    Some more background from the comment section of the above article:
  2. Sid

    Earseeds, Acuseeds

    Chances of this being true = 0%
  3. Sid

    Clinical effectiveness of an online group physical & mental health rehab programme for post-covid-19 condition REGAIN study, 2024, McGregor+

    Carson https://x.com/alancarson15/status/1755477162226770005 “Interesting trial- once again showing rehabilitative exercise is beneficial in fatigue states- there comes a point where @NICEComms is going to have to recognise the harm their anti- scientific guidance is doing”
  4. Sid

    New German Trial for Rituximab? (High Dose)

    I know of a case who had ME/CFS and fibromyalgia for 20+ years, got cancer, received cyclo and was unexpectedly cured of ME/CFS in the process. This was years before the Norwegian rituximab and cyclo studies so probably not placebo/expectation bias. However, the symptoms returned 18 months...
  5. Sid

    Chronic fatigue syndrome and its response to the use of a multimodal antidepressant, 2023, Burca

    Unclear why they thought this was ME/CFS. Typical geriatric depression presentation tbh.
  6. Sid

    Trial Report Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND)

    Abstract Objective: This study assesses response to intravenous immunoglobulin (IVIG) in presumed autoimmune postural orthostatic tachycardia syndrome (POTS). Background: POTS may be associated with autoimmune disorders, serum autoantibodies, or recent infection. Uncontrolled case studies...
  7. Sid

    Rituximab for psychosis (double-blind RCT protocol)

    It’s typical pseudoimmunology you see in psychiatry papers, all their papers are like this.
  8. Sid

    Studies looking at PEM - have they measured PEM or just the response to the challenge used?

    You took the words right out of my mouth. This feeling was like nothing I had ever experienced and it was accompanied by a sense of something being profoundly wrong, doom. There’s no conventional vocabulary that can explain it. It’s not tiredness, fatigue, malaise, or any of this. It also had...
  9. Sid

    Rituximab for psychosis (double-blind RCT protocol)

    Rituximab as an adjunctive treatment for schizophrenia spectrum disorder or obsessive-compulsive disorder: Two open-label pilot studies on treatment-resistant patients https://www.sciencedirect.com/science/article/pii/S0022395622006719 Abstract In this explorative study, we investigated if an...
  10. Sid

    Rituximab for psychosis (double-blind RCT protocol)

    I’m surprised they chose 12 weeks as the primary endpoint.
  11. Sid

    Rituximab for psychosis (double-blind RCT protocol)

    The bone marrow transplant case is somewhat problematic because the donor with schizophrenia was his brother. Having a first-degree relative with scz is a strong risk factor for developing this heritable condition. However, first onset in 60s is unusual, though not unheard of. I’d be more...
  12. Sid

    Rituximab for psychosis (double-blind RCT protocol)

    Abstract Background The role of inflammation in the aetiology of schizophrenia has gained wide attention and research on the association shows an exponential growth in the last 15 years. Autoimmune diseases and severe infections are risk factors for the later development of schizophrenia...
  13. Sid

    NHS England web pages on ME/CFS

    Seeing the word tiredness in association with this condition makes me very angry but I suspect the reason this word is used is because the NHS website in general (not just the ME/CFS entry) is written in childlike language. Other NHS disease descriptions also use trivialising language like "sore...
  14. Sid

    NHS England web pages on ME/CFS

    Utterly misleading to imply that there is a single evidence-based treatment for this.
  15. Sid

    Best chopping tool/food prep gadget?

    I used to call my food slurries. It looked unappetising but better than ending up in hospital battling with them about tube feeding.
  16. Sid

    Best chopping tool/food prep gadget?

    Same. I can't believe how long it took me to discover these time- and effort-saving hacks.
  17. Sid

    Best chopping tool/food prep gadget?

    Stick blender was a literal lifesaver for me when I couldn’t swallow anything. I literally used that thing to purée all my food. Without it I’d be dead now.
  18. Sid

    Best chopping tool/food prep gadget?

    I had a scary knife accident fairly recently which made me realise I was going to have to change the way I do things even if it compromises on freshness/taste (survival first). Since then, I started buying peeled/chopped frozen vegetables. Mostly frozen but there's also fresh stuff like squash...
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