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Letter to the editor by Bourne et al. cites an interesting study I had never heard of with much better methodology addressing the same research question (is POTS fear of standing). Masuki S, Eisenach JH, Johnson CP, et al. Excessive heart rate response to orthostatic stress in postural...

Authors’ reply to Tuller et al. Extinguishing fear conditioning has already been tried. In fact it’s been the cornerstone of treatment of these patients for decades (CBT, GET) and it hasn’t worked. Another letter pointed out that most patients have at some point been told their illness is...

The two papers are looking at two different things. The original BMJ paper he's referring to in the interview found that neuroticism and other psychiatric scales didn't predict ONSET of postviral fatigue syndrome. The Cvejic analysis of follow-up data found that higher neuroticism score predicts...

He also makes multiple false and defamatory claims against patients including that their critiques are non-scientific and akin to climate change denial (at the very end of the interview). He also strongly endorses GET, CBT and cognitive remediation (a treatment for depression btw) in this...

https://support.apple.com/en-gb/guide/iphone/iph5ede58c3d/ios

If machine learning people were interested in a project like this, it should be easy enough to collect large datasets with little cost. Millions of people out there already have a Fitbit or Apple Watch.

In milder cases, maybe. But what he doesn't see is the devastation in the days/weeks after such excursions outside of the energy envelope.

Are efforts being made to enrol people who don’t live on the internet? Were any people with a background in epidemiology or statistics involved in designing this project?

That's a lot of steps, especially for severe patients. When I was severe I was doing less than 500 steps per day. Not surprised to see this. I've long suspected that Fitbit is inaccurate and tracks arm movements. Good study, useful results.

I keep thinking I must be misinterpreting it because there's no way in hell something so absurd would pass peer review. But then again, as we've seen before, anything goes when it comes to publishing research that makes ME/CFS patients look stupid or insane.

GTFOOH. This study is utter nonsense.

I had an almost identical experience, and it was the most demoralising year of my life.

Executive dysfunction is also one of my most worrisome symptoms. It makes it very difficult to get a job, even one that permits working from home. Struggling to maintain a 4-digit code in your working memory, or a phone number you just looked up, these sorts of things are really troubling.

Have you had a chance to check out Fig 3? The patient with elevated anti-Ro antibody, it barely declined with treatment, and they still had quite elevated levels of fatigue after 3 months. Bad news for Sjogren’s?

Having waded through the whole paper now, I don’t see any wrong ideas in it such as T cell driven autoimmunity. Regarding citations or lack thereof, that’s always driven by politics.

Elsewhere they talk about how the patients also lost other autoantibodies. I think that’s what they’re referring to, not T cells.