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This is where sickness behavior might finally yield some relevance. I can think of a number of contested human diseases that could plug and play here, potentially.

Curious to see Baraniuk publishing with Marshall-Gradisnik.

I have POTS and my BP can range quite a bit. Perhaps a more appropriate phrasing would be "In so-called postural orthostatic tachycardia the BP can be normal." I was diagnosed with OI a couple of years before POTS.

Get in line.

As long as a disease like ME/CFS remains contested, a diagnostic test can benefit patients. With disability and health insurance claims challenged far too frequently, and a skeptical public that can include family and friends, a diagnostic that can rise above those challenges would be welcome...

Very cool. Can you tell that I - although a fan of IGeneX - have never used any of its products? I like that they test for more than one strain, and for several species. As I recall, the NIH used to refuse to test for anything other than Bb sensu stricto. This made no sense to me - how do you...

I had the vague feeling immunoblot and western blot were pretty much the same thing, or at least employed the same process. I could be wrong. IGeneX, as usual, simply allows for more bands than conventional testing, including OspC and OspA. Unfortunately, dx will remain questionable despite...

https://igenex.com/press-release/lyme-immunoblot-receives-fda-clearance/

Viruses are pretty much everywhere, of course. Still, this nematode study is curious, if only for potential import. https://www.lstmed.ac.uk/news-events/news/newly-discovered-viruses-in-parasitic-nematodes-could-change-our-understanding-of

Personally, I'd like to see something that reflects the individual nature the disease can manifest itself in patients. (awkward wording, sorry) Something that captures that ME/CFS is characterized by a symptom complex or amalgam. I'd emphasize those symptoms can vary by individual in frequency...

Add bartonella (have a cat?) and babesiosis (take walks in parks or woods?) to that list, at least potentially.

Diseases, and particularly infections, that attack red blood cells are, I think, more common than most people appreciate. Since impaired skeletal muscle function is at play in many such cases, perhaps there is a subset of pwME that may be impacted.

Thanks for the explanation. I thought it might be something along those lines when I read the discussion. Still seemed needlessly psychological when trying to infer organic brain problems. It warrants a slower and more deliberate read-through, if only for the historical Wallit ties.

This "cognitive conflict" reference is unsettling.

@Dakota15 , your effort and attention to detail, and time to register it all here typed in word by word, is breathtaking.

As far as I could ever tell, Marques was loyal to the CDC diagnostic formula, including for spinal fluid. Even so, she would have had plenty of qualified recruits. This idea that chronic Lyme cannot fit into the CDC/IDSA diagnostic paradigm is just a myth. Oddly, Marques knows that, I think...

So evidently Nath felt similarly to me about what he should have been able to draw from the NIH Lyme study.

Right. So she had people who crossed all those hurdles. Remember, we're talking over 15 years of recruiting. a) Igenex sells some good tests. They test for more strains than just B31, and allow 2 proteins/bands, particularly relevant to late stage Lyme, that CDC testing removed due to vaccine...

Maybe. It shouldn't matter. I'd still imagine she'd have been able to pull together a decent cohort. Certainly at least one. Nath sounded bitter to me.

Sorry, but that is incorrect - at least relative to Marques' chronic Lyme/PTLDS study participants. Each had to satisfy strict IDSA/CDC diagnostic criteria before qualifying to even meet with a Marques underling. This is pedigree Lyme shit we're talking - with the population accruing since 1999...