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@Trish, I think their treatment is one (or more) of a grab-bag of common psychotropic drugs given in conjunction with a "connexin-blocking agent" (usually meclofenamic acid) which is claimed to potentiate the action of the psychotropic drug so that it can be given at a lower dose. The patent...

Linkies: Therapist Manual -- ACTIB Trial Patient Manual -- ACTIB Trial

Am I right in thinking that the results of the three substudies mentioned in the trial's protocol have not been published? Even if there were no differences between the placebo and rituximab groups, I'd like to see how the participants' endothelial, cardiopulmonary and gastrointestinal...

My two pennies worth. If tolerated, medication to improve sleep and medication to improve pain. This can involve a lot of experimentation with different drugs, often given at much lower doses than normal. W.r.t regulating sleep and wake times, I think it's more important to emphasise quality...