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From Cort’s blog: "Because Younger didn’t know exactly where in the brain to search in ME/CFS, that technique wouldn’t work for him. He had to develop a method that would produce a heat map and a chemical signature of the entire brain, and found a Florida researcher who developed a way to do...

I don’t know, but why not suggest it? It sounds like a great idea.

The fabulous Julie Rehmeyer, I presume? Welcome to the forum, @Jrehmeyer You asked a good question. The short answer is that biological systems are complicated with lots of things interacting with each other. So just as symptoms are common to many illnesses, some biological findings will also...

Diagnostic tests First 20 minutes of video are about their new diagnostic technologies. My notes, FWIW: Biomarker: the primary concern is to demonstrate that patients are sick, rather than finding differences with other diseases. Nanoneedle chip: uses a single drop of blood (red blood cells...

I don’t know if this, from the blog, is relevant: "Another of the Neale results is that women that have G at this position tend to have very slightly lower lymphocyte count (rs7337312; p = 4.6×10-7; other variants in LD have p < 5×10-8)." they recruited people aged 40 to 69 to increase the...

New blog at ME/CFS Research Review Guest blog by Professor Chris Ponting and colleagues. Summary A new analysis using data from UK Biobank indicates that one version of a particular gene increases the risk of ME/CFS in women. The gene codes for a transporter protein in the mitochondrial...

Spot on. My quoted blog’s opening line did make clear patients’ simple motivation: “Like all patients, what I want most from clinical research is treatments that work, not ones that merely look good on paper."...

The state of my health has spiralled downwards this year and is now dire, so this will be the last major blog from me for the forseeable future. If my energy levels improve, I might in future be able to write some shorter blogs on simpler subjects, which might be a relief for everyone. There...

I'm sure cost is a big factor: the metabolomics analysis in particular is very expensive. Although they have 100/100 patients/controls in the full sample, only 50/50 are definitely included in the exercise study, though Ian Lipkin said they hope to expand that to 75/75. All 100/100 will do the...

Part 2 of the blog about Dr Ian Lipkin's Collaborative, now up at ME/CFS Research Review The heart of ME/CFS? Lipkin’s Collaborative probes the impact of exertion The hallmark symptom of ME/CFS is post-exertional malaise (PEM), a prolonged, grim and disproportionate response to exertion. While...

Good to see that the teaser worked :-). Coming next week

New blog at ME/CFS Research Review The microbiome hypothesis: Dr Ian Lipkin's collaborative, part 1 A gut reaction is the problem in ME/CFS – that’s the main idea being pursued by Dr Ian W. Lipkin of the Center for Infection and Immunity at Columbia University. He believes that the body’s...

I like this: Endpoints: The study will compare pre- and post-treatment differences, in exercise performance and function during recovery, using a combination of objective and subjective endpoints. Objectively, we will measure exercise performance (via blood gases, work, time to ventilatory...

Interesting video, worth a 5 min watch. A few things that struck me: 1. Mark Davis is joing Principal Investigator along with Ron Davis, which probably isn't surprising given that MD is the immunology expert. 2. Bit more about HLA (see my blog on this) They will use new technology to sequence...

Whoops: https://www.nature.com/articles/s41598-018-28477-9 Original post corrected. Thanks. And I'll rest better once the blog is finally out of the door. Pacing perfectly in the meantime, of course...

Nice try! Sorry, don't even have the energy to read the paper. However, I'm relying on the summary from @Trish , and over at PR Murf posted this: Six thoughts 1. They confirm some of the previous metabolomic findings - ceramides and phospholipids. 2. They find (yet) another subgroup that can...

If there is a link between HLA and ME/CFS it wouldn't directly leads to to treatment. However, if HLA are shown to be a risk factor, that would point strongly to an infectious or autoimmune cause. It is possible the finding would help researchers to track down the specific infections/autoimmune...

The biobank sample is currently too small (it probably needs 1,000 patients or more) and HLA genes are hard to sequence for technical reasons. Ron has invented a new sequencing method that he will apply in his new study. Thanks. I had to sort out the risk link gremlin in the source code...