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Thanks, and to @forestglip for the explanations. You could say that a GWAS is essentially scanning all of human biology to find clues about what processes have gone wrong. But with a relatively small study, such as DecodeME at 20k, it's likely you will miss a lot of clues.

What an extraordinary database string is, and brilliantly explained. Also, what a cool red chair in the background

What is A3, Mario? Still means a paper size to me, I’m afraid. Because I thought that was an amazing list, , Including some quite sophisticated points. Basically over my head. I’ve messaged Chris! A few points based on a limited amount I know: I had previously heard that the minimum useful...

Thanks, I hadn’t seen that. I had a feeling I had seen a survey results of a similar question before, but I couldn’t say where. But just to recap the results For those who have PEM after both physical and cognitive exertion: Fundamentally different: 9 (13%) Fundamentally the same: 17 (25%) Some...

I don't remember doing so, but as this was yesterday morning there is no chance I would recall :) Possibly - but a small difference vs none isn't much of an effect. Someone on PR, who I think is here too, did a brilliant analysis of 6MWT results of clinical trials of modest exercise...

That’s very possible. And Negative findings are hard to publish in any field. But I would like to see a better version of this study done that gives us clear answers. I suspect that answer would be a clear-cut negative, which would be useful, as you say – but either way I’d still like to see a...

Do you have any indication of how this group’s severity compares with people who took part in the Pace trial? The six minute walking test worked perfectly well there to expose the problems. But yes, a Fitbit test would be more useful. The Pace trial also did a fitness test, which showed that...

Thanks for pointing that out. As I said, I only skimmed. So, they calculated the right measure, and highlighted wrong ones that looked better? I had credited them with simple incompetence.

I’ve only had the energy to skim the thread and the paper, so this might be a little off track, or repeating what’s already been said. But I think this study is a step forward, for a couple of reasons: – it uses several sensible objective physical measures Which we’ve been calling for for such...

It is, thank you. I think I understand the key metabolic ideas more clearly. Though presumably the central question for any theory to answer is, “how does this cause ME?“ And as you say, this is where you rely on speculation to bridge the gap. I will bow out at this point, but thanks for taking...

Thanks. I was hoping for something more succinct because of my brain fog. From a quick scan of your other post, malate seems to play a central role, but I wasn’t sure if the underlying issue was presumed reduced Mitochondrial reduction of NAD(P). Can you sum it up in a couple of sentences?

Thanks. Presumably, there are vast numbers of possibilities as to what has gone wrong in ME/CFS (I've been reading research papers for 30 years and have come across more than a few). What makes you think this is the answer, and what evidence is there currently? And how would you test your theory?

I'm not sure we have robust data on asymptomatic infections causing LC, given the very broad definition of LC and whether asymptomatic infections lead to LC that is ME/CFS. There is quite a bit of evidence that people with no serological sign of Covid later developed LC-like symptoms, though as...

@Jonathan Edwards mentioned that mental exertion uses little extra energy, so it probably doesn't fit with thinking triggering PEM through simple energy demand. In a nutshell: normal walking burns over 200 calories an hour. Thinking uses maybe 10 calries an hour. Some figures from this BBC...

I think a common experience is that PEM feels the same where it was triggered by physical or mental exertion. I guess one possibility is its mitochondria overload in the brain or in muscles, but perhaps Exertion in either organ (Muscles, cancer or organs, collectively) trigger a more generalised...

The problem with the faster drop in grips strength for me/CFS versus healthy controls, is that something similar is seen in a number of illnesses – it’s not specific. The CPET studies do you see more unusual, but there’s very little comparison data. I believe the one consistent effect is in...

I’m not quite sure what you want with your prevalence citation, but this Louis Nacul in study is interesting based on the British Columbia population survey. 1.1% people self reported CFS, but only a third of these of these met questionnaire-assessed criteria. > The population prevalence rates...

Good grief: clear reporting of a negative result, including that it contradicts earlier positive findings. That might seem like a backward step, but I think it’s huge progress, not least because Arnaud Germain is an impressive researcher from a big group (Maureen Hanson’s)

Thanks. If my maths is right, 20% said they improved with CBT and physical function. So overall, it’s modestly unhelpful, compared with a GET, which is very unhelpful/harmful. and that’s consistent with other surveys – at least according to my rather unreliable memory.

That’s interesting, but inevitably biased since people who did well on it are far less likely to find the survey. What were the comparison figures for CBT/other stuff? A comparison with other treatments is probably more useful.