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I would recommend the hardest thing of all - to do what Alfred Brendall has done with Beethoven's music, and Pablo Casals did with Bach - to read and tell things as they really are, without attention to fashion or rhetoric. In other words to do it well, with common sense but with inspiration.

I think it may have been something that was ready and waiting for observant physicians to identify in the 1970s. Prior to the discovery of penicillin, or perhaps the improved public health after World War II, most interest in joint inflammation was in rheumatic fever - of importance both as an...

Do you have a source for this @Mij?

It is certainly true that not all autoimmune disease show useful benefit from rituximab. However, lupus does benefit - as now confirmed after 20 years with a large controlled trial. Type 1 diabetes may not strictly be autoimmune. There is certainly not much evidence of B cell mediation. It does...

The problem is that it shows up in different directions. Which is no use as science, which relies on things being consistent. Dr Hyde is making things up as he goes along. There is no scientific evidence here of any value. The more patients quote Hyde the less they will be taken seriously.

I was going to write a long essay about why this is a misconception. But I guess I have already said most of it and I will leave it. Maybe. The problem is the implication that somehow publishing a lot of histories together achieves more than each one on its own. It only does if representative...

But if Whitney Dafoe can pull a face like that, that is maybe one thing to be thankful for.

Yes, it begins to look as if a vaccine is really not such a magic answer. Judging by last April the UK could reduce rates tenfold in just over two months with effective social distancing measures (i.e. 'lockdown'). In another two months that could be a hundredfold. And if one factors in an...

But this is not 'data integrity'. It would be great if it was, but it is almost certainly grossly biased and obfuscated, simply because data gathering almost always brings those problems with it unless you work hard to avoid them. I think I understand the illness of ME because I have sat and...

My point is simply that asking patients to list symptoms is exactly the right thing to do and is the basis of all clinical assessment. But averaging out a lot of people's lists on graphs does not make the information any more useful. If anything is confuses things. That is why I always like to...

The sentence that stands out to me is: This is the quickest way back to some degree of normality. Everything seems to be seen in terms of a quick fix to get back to selling stuff. Having more people slightly moire immune seems to me to be a a recipe for going nowhere fast. Lots of people will...

This study is by far the most accurate depiction of the illness I have seen, in terms of capturing the whole of the experience, despite being incomplete. But, with respect, we do not know that and it probably isn't. Each panel seems to show an average time profile and that is not the reality...

I would be more cautious about the validity of a study like this. Having looked at the 'Body Politic' site I think we have to consider to what extent this will be a biased sample in all sorts of ways. This is why I think DecodeME should steer well clear of international recruitment because the...

The vultures are circling - and babbling as they fly.

That is the likely situation but it is not certain. If 90% effectiveness is defined in terms of blocking clinical symptoms then the effectiveness in preventing death may be greater roles than that. Your person considered to have a 99% chance surviving is effectively one of a population of 1000...

I think we are all going to need to continue with full preventive measures whether or not we have either vaccine. That is certainly the case for the Oxford vaccine and there is no guarantee that the Pfizer vaccine will be quite so good in practice in a UK context. When people talk of a useful...

The 'patient centred approach' no less.

Babble and Squeak.

I don't actually think you should get muscle biopsies from healthy people. It is very painful and likely to leave scar if an adequate sample is taken. I alsodonot see why it is any different here from the US. Itmay beard total biopsies in a private clinic but then you have to ask why it is hard...

Oh dear me.