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Agreed.

Not if nobody knew what they thought was the best dose. The clever thing about a dose response curve is that it emerges out of the results from lots of different people. Each individual result is clouded by the risk of bias but there is no reason for that bias to produce a predicted curve. If...

In many ways the best sort of trial is a dose response study. Dose response profiles are much more convincing evidence of efficacy than simple test-control differences. Moreover, dose response trials can be done without there being a group that seems to get no treatment. Bias problems are much...

I don't understand these points. If physicians in a service are already using a drug liberally off label the presumably the admin don't really care about ethics and are not going to complain about doing a proper trial. The cost is already going through the system. I thought that Abilify was...

So why do they claim to be world beating ME research experts, pray? All medical students get the training. Beyond that all you need is common sense and being careful. I know because I never had any training beyond what I had at medical school. I set up trials using common sense and consulting...

Thanks to those with more persistent searching skills than I can muster. It is certainly pretty hard to see who is making these claims. But all is clear now.

Yes, but that does not say who they are -in terms of real people.

Who are 'ME International"? The links from that 'position paper' don't tell me much.

Nobody is assuming anything other than what you suggest. That is obviously what they have done. The problems are: 1. That they should never have been in the situation of reviewing 70 cases of CFS treated with Abilify without having started a trial and if the cases were treated for something...

Do you have any evidence for casual retrospective record reviews showing less than 74% of cases reporting improvement on at least one of several endpoints? I think you are thinking of rates of improvement in prospective trials according to predefined criteria. Even in the PACE trial control...

We need something more professional than this to get anywhere. Why is a retrospective review being done rather than looking prospectively? If patients are assessed retrospectively we need details of the indications for treatment, the nature of the referral pattern for the clinic involved, the...

Indeed, infectious disease physicians see people with ME/CFS very regularly. Totally underwhelming.

I think the paper implies that systemic nickel allergy is indeed myth - although they may have wanted not to be too up front about that.

Moved post Familiar marketing stunt in the Guardian just now: "It doesn’t stop when the virus is under control and there are few people in hospital. You’ve got to fund the long-term consequences." From the President of the Royal College of Psychiatrists...

This seems to me very important. If someone comes to believe, having read a website, that they have a specific brain disease called ME that shows up on scans with diagnostic defects then they likely to suffer two problems. Firstly, most doctors will think they are deluded and hypochondriac...

I think both the original terms are fine. The variant carries mutations - which cover any random genetic change.Very likely the problem is down to one particular mutation. Evolution does not have to require selection. Darwin was completely wrong about that. The Galapagos finch radiation need...

I don't think this is the same as a multidisciplinary team though. Yes, an arthritis patient might need a surgeon or an occupational therapist. An MS patient might need a physiotherapist or a dietitian. But there is no problem with management by a physician who makes individual referrals when...

So you know a lot about other diseases, Guido? You are entitled to your idiosyncratic views but please be aware that dogmatic statements about a so-called disease called ME may confuse and perhaps harm other people. You have asked me what CFS is or what ME is, but it is you who are making these...

Maybe it reinforces the impression from ME that exercise has a really rather poor placebo effect. Purple elixir would probably do better.

Because ME/CFS is an agreed term that means 'that which can be either called ME or CFS'. The term is purely a concession that recognises that different people prefer one term or the other. If you want to be well informed about what physicians think about ME/CFS then you need to know what ME/CFS...