I don't think there is any benign mechanism whereby viruses tend to get less virulent. It is the other way around, as Trish says. If they get less virulent they are more likely to be tolerated and become endemic. Smallpox never got less virulent, nor did measles.
Another way to look at it is...
A very good question. It matters whether the variant survives longer in droplets or on surfaces or is produced more profusely by presymptomatic individuals or infects at lower dose number or... whatever.
I am not sure anyone has any idea yet.
I am pretty sure that the surge in cases in the...
I actually have some concerns about the material Solve put out. This came up because we discussed my providing a Q and A session, which hopefully we will do.
The statement quoted: But, after the invention of the MRI machine, which provided images of lesions on the brain and spinal cord, the...
I disagree. The PACE trial came from the received wisdom. ME really has been seen as mostly psychosomatic. MS was never in any way comparable. Solve were clearly suggesting an analogy and there is none. Those who claimed that MS was psychosomatic after 1950 were akin to Gwyneth Paltrow and Goop...
Sorry but I don't think this is the case. The great majority of cases of MS can be diagnosed clinically. The difficulty is that in clinical terms the key feature that distinguishes the disease is recurrent attacks with remissions. So it is difficult to diagnose MS rather than some other organic...
People can have MS for fifty years and is intermittent so there may be attacks with confusion and loss of mental function that improve considerably. As I said, some early cases might have been misdiagnosed as hysteria but the key point is the this was not a matter of general policy - it was just...
This simply cannot be the case, as @Nightsong points out.
Some people with MS develop dementia as part of the illness.They will have been on psychiatric wards because that is where people with dementia went, whatever the cause. I remember visiting psychiatric wards as a student and people there...
Interesting to see comments from Derek Wade:
I cannot see how you can draw any clinical, conceptual or other logical difference between the syndrome, and the areas that you are deliberately excluding such as chronic fatigue syndrome or post intensive care
syndrome. Syndromes, by their very...
Isn'this fromGreenhalgh pretty fair: ?
Recommended management for most patients in the outpatient setting, whose symptoms tend to be nonspecific and dominated by fatigue, consists of emotional support, ongoing monitoring, symptomatic treatment (e.g., acetaminophen for fever), and attention to...
Drugs that kill one organism and not another often have toxicities. A very general rule but not a bad one. Moreover, a quick look at PubMed suggests that Ivermectin may be teratogenic and the best figure for relative risk for fetal malformation is 1.69. The worst part of that is that billions of...
I don't think that is right. Peer review is not in any way dependent on what government bodies do. Government bodies come along late in the process. The first thing is for scientists to publish - which includes peer review by colleagues who are usually very ready to do so. Incentives for drug...
I don't understand that. NIH review is not peer review. Peer review occurs at journals as soon as data have been submitted, nothing to do with NIH. If nothing has been considered worth publishing in a journal things must be pretty bad since nowadays some journals publish pretty much anything.
Perhaps the problem for those with 'Long Covid' is that if they want attention they don't want to acknowledge that there are already (in the UK) about 150,000 people in the queue who have been waiting a while.
I am amazed that this appears in the Lancet (if it did). It seems to be a lay group who want to invent a new disease called Long Covid based on the same sort of phoney science we have seen so much of for ME. The call for including masses of symptoms in criteria is familiar and completely...
I guess there may be confusion about who is writing what document. Turner-Stokes and Wade have produced a document for the British Society of Rehabilitation Medicine on Long Covid - which may be why they were invited to comment of the ME/CFS draft.
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