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This is just plain bad. I hope it is rejected for publication because stuff like this is totally unhelpful. I am used to manuscripts like this from therapists doing higher degrees wanting some papers for their CV but to have something like this from someone who is both a professor and a member...

Erhem. I had published the rationale earlier that year, based on a hypothesis that involved 55 precisely defined interconnecting steps. I knew exactly why it ought to work!!

Maybe I am being dim but I am surprised by the absence of any reference in the abstract to the huge increase in percentage in the female 18-29 group. Does this mean they do not think it is reliable? And does that imply that none of it is reliable? Or what?

So now evidence is dispensible. It all reminds me of Jeremy in the Yellow Submarine

Total hot air from Greenhalgh plus the multidisciplinary rehab mantra again (with no evidence yet evidence based). The clanging of empty tin pots is getting deafening.

Still 'following' the science - following a month late that is.

My question would be how anyone can know what is the 'most appropriate' therapy' when there are no valid trials of any of them. One of the things I focused on at the NICE committee session was pointing out that if effects are of the sort of size suggested by PACE then it would be completely...

Why does practical and emotional support have to be called CBT at all? CBT is about changing behaviour through changing thoughts. There is no evidence for that bering relevant to ME or likely to be. I see it as something quite different from support, which is free of any cognitive theory base...

That is something a bit different. Sure, there will be reviews that conclude no effect. But what if a range of studies provide some weak evidence of effect, some moderate evidence of effect and some strong evidence of no effect. What I have not seen is evidence for no effect being graded in the...

What I wonder is whether reviews ever take note of strong evidence for NO EFFECT. We always hear of weak or moderate evidence for an effect but PACE provides strong evidence for NO EFFECT at least for some outcomes and at least moderate evidence for NO EFFECT as a whole.

Well presumably it is that people could not notice the difference between a single session and an eight week course. It could be tricky I guess, if you had brain fog? Sometimes I wish I tweeted, but only for very short periods. Otherwise I am very glad I don't.

But those are not interests in the sense that is relevant. An interest is some potential benefit that may accrue, not a belief or experience. Nobody is focusing on those. This resounds with rationalisation with deliberate confusion of term usage. Again, the message in the background is that big...

The whole study is meaningless. I don't see how you can talk of sensitivity and specificity when you are just comparing two sets of criteria - although the fact that they differ so much is certainly a clear indiction that one or other or both are pretty useless. There is no comparison for lupus...

Steven Holgate may speak for himself but I don't think he can say Covid-19caught us all by surprise. A lot of people with expertise in the field, as well as a lot with general medical knowledge, were entirely expecting it. Moreover, the failure to respond had nothing to do with it being...

Yes, I looked up a while back and it certainly does not have to be financial.

I am not sure that anyone needs to draw attention to this. It is transparently obvious to everyone. It is just that how people then pump out hot air on twitter varies a bit. Nobody misses the connection, even if they skirt round it. Useful research will depend on someone intelligent making an...

As someone who does not understand these newfangled things -what is the point of a private twitter account? It sounds a bit like an opera singer being confined to their dressing room. I have no motivation to tweet but I do find it revealing. Anyone who tweets 'honoured to be part of this great...

It might be the case that women have fewer mitochondria but the statement sounds totally unsubstantiated. Dr Strain sounds like a biota a dabbler-geriatrics, diabetes, vascular, Covid, chronic fatigue...

Politically astute in that she knows how to keep her profile high and that of the current primary care agenda. Not so astute if she actually wants to achieve anything of value. Primary care in its present form will disintegrate over the next decade, as it should. Nobody will want to work in it -...

I am not quite sure what you are implying @Andy. Surely this £10m is just going the way of all the other multidisciplinary drivel - employing people with no idea what they doing to turn a political handle. it is already established that people with 'Long Covid' have no demonstrable reason for...