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Salubrinal came to our attention via the Hwang study on WASF3. That study showed endoplasmic reticulum stress was causing WASF3 production and the WASF3 was screwing up energy production in the mitochondria by affecting supercomplex formation. (supercomplexes allow the mitochondrial membrane to...

I've encountered references to matrix metalloproteinaise a few times recently. https://en.wikipedia.org/wiki/MMP9 Its functions relate to the extracellular matrix, and [speculation follows] perhaps one reason science has struggled to find the answers to mecfs in the cell is that the issues are...

SHe replies: Glad to hear from you and thank you for your interest in the work (not a lot of it in this space, as you perhaps already know). Unfortunately, this is an abstract of the research I am presenting at a conference. The manuscript itself is submitted to a journal and we are waiting to...

My read of their other papers suggests the distinction is not that it is 3D printed, but that other researchers are using 2d layers of muscle cells, which don't fully capture the behaviour of muscles in certain conditions. They have these little slivers of 3d muscle and they seem to be able to...

There's a 2023 paper here that talks about the history and process behind "3D muscle models". Muscle-on-a-chip devices: a new era for in vitro modelling of muscular dystrophies Juan M. Fernández-Costa,1 Ainoa Tejedera-Vilafranca,1 Xiomara Fernández-Garibay,1 and Javier Ramón-Azcón1,2,*...

Is this a PEM model? we need so desperately to have a benchtop model in this disease. Working on people is so slow, expensive and variable. I didn't see this coming but I am excited by it. To be fair, "3-d in vitro skeletal muscle tissues" don't sound super cheap and easy to get! but they have...

Good to have this hypothesis formalised and published. I'm a little skeptical of how widespread this could be as an etiology of mecfs but perhaps it is a subset. To be clear the author, Bateman, is not well-known ME/CFS researcher Lucinda Bateman of Utah. It is instead two Batemans from NSW...

Small sample but they do also blend two other cohorts in and look for commonalities. This is not game-changing research or cure-finding research but it probably help tip the funding paradigm slightly in the direction of EBV and neuro issues. And when DecodeME comes out (suppposedly in August...

I'm sharing this because it's an example of a metabolic issue with a barrier component. And involves STAT singalling, which I know the stanford people are investigating. It's also quite hopeful because they seem to be onto a fix with IL-22. The applicability of this to me/cfs is completely...

IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis Peng Zhang 1 , Junlai Liu 1 , Allen Lee 1 , Irene Tsaur 1 , Masafumi Ohira 1 , Vivian Duong 1 , Nicholas Vo 1 , Kosuke Watari 1 , Hua Su 1 , Ju Youn Kim 1 , Li Gu 1 , Mandy Zhu 1 , Shabnam...

I think sit / lie flat is an interesting dichotomy but legs up is a very important intermediate. I once had an office job where I wore a suit and I'd sit on my swivel chair cross-legged because it was the only way I could get through the day. (spoiler, by the end I could not get through the...

I'm always interested in any hypothesis with an adrenergic connection. beta blockers have been very useful for me, as has midodrine, an alpha agonist. I think vasomotor control by adrenergic receptors is part of the symptom set and we could certainly use upstream explanations of that. You note...

Berlin Cures will reveal the results of the BC007 Phase II trial in November at a Long Covid conference. https://www.berlincures.com/en/news/demystifying-long-covid-interntaional-conference-2024 "Dr. Oliver von Stein, CEO, and Dr. Axel Mescheder, CMO, will represent Berlin Cures at the event...

Excellent group of test subjects. I hope they have continued to follow up with them and seen how their health goes beyond 60 days. From 1170 covid infections you would probaby expect 400 to have some lasting symptoms at 3 months, maybe a third (130 ppl) of which is they can't smell or their...

You can see some level of self-selection in my response to the email from Baker institute: > thanks for the email. I'm probably going to hold off on this. My health has been retty tenuous recently and I can't afford a setback. I'll get in touch later in the year if I'm feeling more up to it...

Here's the PICF. It contains some language that will make some people concerned. And some stuff that looks good. The language some people might be concerned about: " It will also help inform people with ME/CFS what levels of activity might decrease the risk of PEM and guide doctors in designing...

I contacted them earlier in the year but then backed out of actually doing it as I was in a downward spiral at the time and worried about gettin worse. Here's the email they sent me. I think the research objective looks good and I should follow up with them! Hi , Thank you for completing the...

Pleased to hear this stands up because it's one of those things where I wasn't sure if it was folklore. I've heard it repeated a lot but also seen it questioned in these pages. A solid finding is a relief.

So just to clarify what you two are finding: there is a small difference between mecfs and healthy on a 2 day cpet ? Is that the top line?

I'm just hearing about paneth cells and they seem interesting. Here's two papers. First a background primer on how they maintain intestinal homeostasis. Those of us who seem to be in constant dysbiosis might wonder if our paneth cells are working properly. EMBO Mol Med. 2023 Feb; 15(2): e16427...