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What was in common between Younger's video above and Cort's write-up is emphasis on the increased volume of research now (and increased number of researchers) and the collaborative approach. Younger says some good basic research will come out soon. I suspect his mention of subgroups is a way of...

This is a blogpost by an anatomy professor. I appreciate how he's not defensive about the fact that much is still to be known in medicine, rather he is excited and frustrated to get on with finding things out.

https://svpow.com/2024/09/07/were-not-going-to-run-out-of-new-anatomy-anytime-soon/ We’re not going to run out of new anatomy anytime soon September 7, 2024 If you are interested in making anatomical discoveries, good! Because relative to a single human life, the work to be done is...

I've just started reading this and there's a subtlety in it i appreciate. They distinguish exercise intolerance from PEM: Importantly, PEM is clinically often accompanied by fatigue and profound exercise intolerance. Yet, while being pathogenically connected, they constitute separate entities...

No difference visible in Hanson's four-timepoint metabolite study for 2-hydroxybutyrate, but a group difference for 2s-3r dihodroxybutyrate that kept increasing the more exercise the particpants did, until healthy control had more. The above chart taken from my interactive webapp that gives...

Stress granules are confusing. The only thing I know for sure is they need a rebrand, ought to be named something latinate and technical to get respect!

Phair and Davis are interested in the Jak-Stat inhibitor that de Meirlier uses, Filgotinib. They think it can turn off innate immune reactions and therefore address some of the fundamental issues in me/cfs. I admit I'm attracted to the idea that innate immunity is stuck on. It is plausible...

I'm always pleased to see scientists operate with open minds.

On Reddit someone linked to a Robert Phair comment on Health Rising where he indicates the Australian patient Ron references was corresponding with him, Robert Phair. The patient had gone to Japan to seek Filgotinib, and got better within three days. IN this webinar Phair also cites an anecdote...

This is the second potentially relevant sickle cell paper I've sen this week, I posted the other one here: https://www.s4me.info/threads/less-deformable-erythrocyte-subpopulations-biomechanically-induce-endothelial-inflammation-in-sickle-cell-disease-caruso-et-al-2024.39940/#post-550623 I've...

NEGATIVE TAKE This is a hypothesis paper. I made a comment in another thread recently about how easy it is to make up credible theories of mecfs. They're easy to generate. Useful, but cheap to make. What we really need is to match the rate of hypothesis generation with high-speed falsification...

I don't think this is likely to be a primary cause of trouble in me/cfs. But, there were those provisional findings from Stanford that RBC deformability was reduced in mecfs. If that is true - and i'm not sure what the status of replication of that is - it could be in the mix of reasons...

Emory University School of Medicine, Atlanta, Georgia, United States. Full text links . 2024 Aug 23 DOI: 10.1182/blood.2024024608 Abstract Sickle cell disease (SCD) is canonically characterized by reduced red blood cell (RBC) deformability leading to microvascular obstruction and...

I'm not 100% convinced that the term boom and bust is pejorative; to me it's merely one way of describing pem. And I'm for anything that centres pem in discussion of me/cfs.

My experience of hanging out in forums and reading papers relentlessly for the last 7 years or so is this: Credible, plausible theories of mecfs, that fit the existing evidence and explain the symptoms, are as abundant as grains of sand. The existing evidence is spotty, the symptoms are...

I love when this sort of step forward happens in basic science, allowing us to see what is happening in cells at a basic level. I bet some assumptions get overturned! For us, I bet there's many uses. One occurs to me: This may be a way to test the purinergic signalling theory (atp is a...

A clincial trial on glycocalyx repair is starting soon, by Klimas.

Just hooking onto this most recent mention of the glycocalyx. Was watching the Nancy klimas talk from IIMEC 2024, and she discusses the glycocalyx, a structure I'd never before heard of and which is only rarely mentioned in these pages. They are running a clinical trial on a substance that is...

It does seem different although I think technically his finding is bh4 as a % of total biopterin rather than absolute levels. His work is also n=1 and the model patient is who you think. Ron says he gave Whitney some synthetic BH2 which made this ratio even lower and Whitney felt much worse.

Fascinating story. Most people are interested in the power angle, who can shut down an investigation. And that's important. But what I'm interested in is the mention of prion disease. Prions are amino acids that can make other amino acids take on their shape. In essence they are contagious...