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They only recently discovered the brain's drainage system, a bunch of tubes that has been labelled the glymphatic system. Its function correlates with cerebral blood flow. If we don't get enough blood into the brain, we can't get the rubbish out of there. Cerebral blood flow is very much...

That's quite a good blinding technique, and a decent result! I'd like to see more data but it certainly appears as though Malic acid works for you. If hope the result continues and if there is a subset, I wonder how big it is! However I worry sometimes about the reception for simple treatments...

Been thinking a lot about cerebral blood flow, which is plainly impaired in POTS. I'm fascinated by the comorbidity of POTS and me/cfs. Could diverse symptoms share a common cause in some cases? I sometimes can't put down occam's razor, even when I am at risk of cutting my finger. Anyway, I...

This is a fascinating hypothesis. Are there other types of tissue that serve as reserve energy? As I understand we use up phosphocreatine, and glycogen, then the body tries to burn fat. But perhaps other things are being burnt too and they're meant to be used only in crisis? Muscle is one...

At the risk of being pedantic on the any .... Hwang's study on the patient with Li Fraumeni and mecfs showed this. "Measuring the regeneration of phosphocreatine (PCr) after its utilization by exercise in skeletal muscle using 31P-MRS can noninvasively assess mitochondrial ATP synthesis...

You have to love when vague, general pain symptoms end up having an identifiable neural basis. Another one taken from our old friends the psychologists by good science.

love it. I'm all for exploration of samples that are easiest to collect, least invasive, easiest to send by mail. That's how you cut costs and lift sample size. Obviously if it shows nothing it's not worth it but we've recently seen some interesting results in saliva and urine. Not everything...

I found that survey to be a bit of a pigsty. Didn't ask any questions that might have got information from me, and I have quite an extensive employment history during mecfs. Garbage going in ....

Emerge ran a competition for the best story about Long covid. the winner was Hayley Gleeson, published at the ABC: https://www.abc.net.au/news/2024-06-16/children-with-long-covid-dismissed-doctors-myth-virus-harmless/103959078 your boy murph was a runner-up in the comp.

I'm keen on this kind of basic epidemiology, I have suspicions that populations are not equally prone to me/cfs even after controlling for pre-existing health outcomes. I have been prone to thinking of me/cfs as a disease mostly of the north sea populations and their diaspora (my forebears...

Very nice explanation. You're an asset to this forum, thanks for all your contributions!

authors: Stanford Journal: PNAS. cases: 650 controls:661. p-values: some very low indeed. tl;dr this study is more likely than most to have found something that is true. That is exciting since what they have found looks relevant and novel.

This idea of heteroplasmy could also be relevant to mecfs: you need have the genetic problem in only some of your mitochondria for symptoms to develop. It would be an obvious way to distinguish mild moderate and severe.

Whenever I read about people having problems with the various complexes in the mitochondrial chain I think about Hwang and WASF3. He found in his patient that WASF3 inhibited two complexes joining together to make a supercomplex, which would run more efficiently (and then detected high wasf3 in...

Got excited by the title, but this is a single author hypothesis paper. To stand up the hypothesis will require a bunch of funding.

Doesn't look like too much to me? They checked 94 million genetic variants in patients, found 398 differnt mitochondrial ones in patients, there was one pathway that had variants in five/13 patients, being the Mucin von willebrand pathway.

There's lots of known unknowns in this space like plasma vs serum; pbmcs vs skeletal muscle; sample storage; collecting samples at different times of day, after different amounts of exertion, etc. There's also biological sex and disease duration which muddle things up. And severity. All of...

I emailed Walder and he said : "No drugs yet from the me/cfs study, should be finding some later this year if all goes well". He understands as well as we do that when a drug emerges from this process it is merely a candidate; the process increases the probability that this compound may help...

Look, I also don't think this is the research process most likely to lead to a cure. I do find myself attracted to a philosophical approach that seeks glimmers of light, even amid human and institutional frailty.

There's a small blurb here about the work Deakin are doing on me/cfs: https://med-projects.deakin.edu.au/projects-2023.php yes, they write me/csf some of the time! Like many new studies it's being done by people who've wandered into this field from elsewhere; that lack of deep background...