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as for myelin, there was a Stanford paper last year that hinted indirectly at dymyelination: Abstract Here we report preliminary data demonstrating that some patients with myalgic encephalomyelitis/chronic fatiguesyndrome (ME/CFS) may have catalytic autoantibodies that cause the breakdown of...

In economics we say "all models are wrong, some are useful". It remains to be seen if this is one of the useful ones, but I very much appreciate the idea of developing animal models: it's how you get high-throughput science. I've often wondered if we could simply try to generate murine mecfs...

Good point @SNT Gatchaman and I've edited my post above.

I was able to find a list of side effects at that link shared by @josepdelafuente above and they include a 1 in 10 chance of reduced sense of touch. That seems like a rare side effect and it is a side effect of amifampradine, listed as a 1 in 10 chance by the EU...

Yes, I'm advocating for the research to proceed. However I dont think it's quite in the same risk category as some drugs. It is used regularly in sports doping. Iga Swiatek was recently banned from the WTA tour for taking it!

Ebselen is a decent guess, it's a glutathione mimetic and the most recent study of Beata Godlewska was measuring glutathione in me/cfs. But the dosing is very different, the protocol for me/cfs looks to be 15mg ramping up to 30mg, whereas they're handing out 400-1200mg for other conditions. And...

edit: Walder is not involved in this study! they're just trying their bipolar drug on me/cfs! !! fingers crossed it helps and I'm sure we will learn something but the theoretical basis is effectively absent. Walder's in vitro work continues this year and he still hopes to get to a clinical...

I got a continuous glucose monitor ($15 introductory price) and so far (only 48h so far) it has been fascinating. I don't seem to have glucose problems in the day or when I eat a bunch of carbs. But at night if I wake up feeling thirsty apparently my blood sugar is low. I wake up, visit the...

Sometimes a literature review like this can be the first step before starting a project. Perhaps this final line of the abstract is an alley-oop for the next phase of work she will be doing? >However, further research is required to determine their specificity to ME/CFS and adoptability for...

I couldn't understand this at first blush but it seems like the proteasome is a organelle-ish type thing in the cell that breaks down proteins; upregulation could be a sign of ER stress, is that the idea Daniel? The Roles of the Ubiquitin–Proteasome System in the Endoplasmic Reticulum Stress...

i appreciate Baraniuk writing this paper. If I recall correctly he got the big bucks from the NIH and he's doing the right thing by us here, wringing every last drop of possible information out of his samples. I particularly like the way he is using multiple different statistical techniques and...

The other finding screaming out for replication is Hwang's WASF3 finding but could you even see it in blood? He used muscle biopsy samples. What you can measure in serum apparently are the Endoplasmic reticulum stress markers GRP78, PERK and CHOP which were also part of his finding (noting that...

I'd love to see the theory that peroxisomes are dysfunctional (Che, Lipkin Bridges 2022) investigated by checking the plasmalogen content of erythrocyte membranes. We have developed a test method for the simultaneous quantitation of C16:0, C18:0, and C018:1 plasmalogen (PG) species and their...

7 month update, I can't rule out the possibility that plasmalogen supplements have helped me, I have felt a bit healthier / better over the last six months, been doing more exercise. Quite a few papers have come out on plasmalogens too, including these two that involve dietary supplementation...

I remember a long thread about purinergic signalling; what I learned from that is that eATP 1. breaks down fast 2. operates on the cell it came out of (autocrine signalling) and a few nearby cells (paracrine signalling). 3. exists in a thin, tiny "halo" around the cell So you can't expect to...

I think this is a good point and even among the various covid variants we might be able to tease out why early variants seemed to cause more long covid than more recent variants. Are enteroviruses our major lead on the most likely type of virus to leave lingering symptoms?

Hanson has been vocal about the possibility that specific viruses create specific responses and Long Covid migth be distinct from ME/CFS. I recall watching a speech where she was quite cross on this topic. I think she's probably wrong but I respect the approach. To my eye the more important...

This is great research for Alzheimers. Finally lifting their eyes from the amyloid clumps to think about other brain processes. Could be just what they need to get this disease out of what may be the biggest dead-end in current research. There is potentially useful spin-off for us if the...

Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy Wesley Brandao 1 , Nimansha Jain 2 3 4 , Zhuoran Yin 1 5 , Kilian L Kleemann 1 6 , Madison Carpenter 1 , Xin Bao 2 3 4 , Javier R Serrano 2 3 4 , Eric Tycksen 7 , Ana...

You love to see drugs getting tested, even when the cohort definition is a bit iffy. This one seems to have come out of left field. I looked through the clinical trial data and it wasn't obvious who the researcher behind this is. The only name I found was this guy who is the boss of virology at...