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Very interesting, thanks. Sounds like it could make for a good movie.

Well now I'm curious. Why are there people who care whether it's T cells or B cells? Just because that's the ones they've been working on thus far?

Cool, I appreciate the insights!

Interesting, thanks! I'll take your word for it if you say the neuron related scores aren't particularly interesting. But when I look at the number of neuron components, it seems like a lot near the top? I see that six of the top ten components are related to neurons (at least based on the...

I now see that this Zhang model is more telling us about clusters of genes with related function as opposed to the specific genes picked out. And I've been learning about GSEA the past few days. So I wondered, if I did a GSEA on the rare variants for chronic fatigue syndrome in the Genebass...

Plasma protein biomarkers for long COVID-19: Predictors of symptom severity and mortality risk Kaleem Maqsood, Shaaf Ahmad, Azeem Saeed, Nabila Roohi [Line breaks added] Highlights • Plasma fibrinogen and haptoglobin identified as biomarkers for long COVID severity. • Elevated...

Interesting since there's already an ongoing trial of maraviroc for long COVID: (Thread) Protocol - Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid [tenofovir/emtricitabine or maraviroc]

A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Sequalae of Covid (PASC) Brief Summary The IMPACT Long Covid Treatment clinical study (IMPACT-LC) is testing two...

Thanks for giving some reassurance at least.

Sure, I don't know how large of a CI would be expected if they had only run it once. I was just worried that it would actually be much bigger and cross 0.5, and that the genes may just be more or less random, and they happened to get 0.670 by chance on the test set. I'm thinking more about this...

Thanks @jnmaciuch. So maybe not quite as exciting as what I thought was happening which did seem too good to be true: lots and lots of synaptic genes coming up independently. As far as I understand your description, it's something more like, if the model sees some variants in, say, both NLGN1...

Using Single-Cell Raman Microspectroscopy to Profile Human Peripheral Blood Mononuclear Cells Elizabeth Gan, Megan Stoker, Edie Guo, Karl J. Morten & Jiabao Xu [Line break added] Abstract A reliable, validated test would enhance our ability to treat and research chronic conditions. Early and...

Are you saying that the way their model works is, if, say, one DLGAP is very useful for the model classification, that makes it more likely for other DLGAP genes to also have high attention scores, even if potentially there isn't much difference between the cases and controls for the others?

The rankings in the Biobank data for chronic fatigue syndrome for these 115 genes might be interesting as well:

And in case anyone's curious about which of the 115 Zhang genes are most significant for depression, here are the 115 genes with their rankings out of the 18,358 total genes tested in depression. You can check here on the depression page, sort by P-Value SKATO, and verify that HOMER2 is the 44th...

I wanted to dig into that chart of phenotype associations (fig. 5: depression, COVID, etc). I realized the data they used is all on Genebass. I tried to figure out how to work with all >4500 phenotypes, but I couldn't figure out how to access the bulk data which is hosted in Google Cloud...

Two better answers than I could have given above, so hopefully that's sufficient.

Albuminuria and Mental Illness Risk: Results From National Health and Nutrition Examination Survey 2005–2018 and Mendelian Randomization Analyses Yangyang Wang, Sen Li [Line breaks added] Background Recent evidence suggests a link between albuminuria and mental illness. However, whether this...

Full paper now published: HIV Infection and Long COVID: A RECOVER Program, Electronic Health Record Based Cohort Study Kellie L Hawkins, Dima Dandachi, Zoe Verzani, M Daniel Brannock, Colby Lewis, Sajjad Abedian, Sohrab Jaferian, Shannon Wuller, Jennifer Truong, Margot Gage Witvliet, Gretchen...

Recent article about ubrogepant for migraine prodromal symptoms (link to thread): Ubrogepant for the treatment of migraine prodromal symptoms: an exploratory analysis from the randomized phase 3 PRODROME trial (2025, Nature Medicine)