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A simple platelet biomarker is associated with symptom severity in major depressive disorder Aksu Gunay, Steven D. Targum, Alex D. Leow, Olusola Ajilore & Mark M. Rasenick [Line breaks added] Abstract Previous studies have shown that the heterotrimeric G protein, Gsalpha (Gsα), is ensconced...

Whole-body hyperthermia as part of a multimodal treatment for patients with post-covid syndrome – a case series Jan Vagedes, Thomas Breitkreuz, Victoria Heinrich, Mohsen Sobh, Mohammad Oli Al Islam, Katrin Vagedes, Jan Mergelsberg Background Post-Covid syndrome (PCS) has been an ongoing...

Now published: HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity Karen Giménez-Orenga, Eva Martín-Martínez, Lubov Nathanson, Elisa Oltra [Line breaks added] Abstract Research of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and...

Living with myalgic encephalomyelitis/chronic fatigue syndrome: Experiences of occupational disruption for adults in Australia Chelsea Bartlett, Julie L Hughes, and Laura Miller First published online May 27, 2021 Introduction Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a...

Using time diaries to inform occupational therapy practice for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An exploratory study Rachel Roxburgh, Julie Hughes, Wendy Milgate Introduction Myalgic encephalomyelitis/chronic fatigue syndrome affects an individual’s occupational...

PolyBio study now on ClinicalTrials.gov: Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19

Oh I think "on the basis of" means the study group received the control group intervention plus SGB: Edit: Maybe. I'm having trouble finding other papers that use that phrase. And that's not an official definition of that phrase. And the quote @Utsikt posted seems to say they got one or the other.

I'm confused about whether there was blinding. There's a paragraph talking about how everyone was blinded: But it seems like the control group 'received psychological intervention combined with estazolam tablets' and the study group received the stellate ganglion block. There's no further...

Efficacy and exploratory analysis of potential mechanisms of stellate ganglion block in alleviating sleep disturbance in generalized anxiety disorder: a randomized controlled trial excluding comorbid depression Na Liu, Qinying Ma, Moqing Zhou, Lin Yang, Wenyuan Wang, Yanyong Wang [Line breaks...

Another Khan Academy immune system section from a different course. I've only skimmed both, but I think this one might be more basic: Types of immunity and the immune system

But would you not expect that a decent chunk of the people in the depression group in the BioBank might have ME/CFS? It might feel different when you know the differences, but if a patient has ME/CFS but they or their doctor don't know about that condition, I think many people would assume they...

The NICE guidelines may be useful, specifically this document: [G] Evidence reviews for the non- pharmacological management of ME/CFS It has the detailed analyses of all the studies they looked at. The overall conclusion for CBT begins on page 372. And the conclusion for GET begins on page 383.

On looking again, I realized I misunderstood this. C2_v2 COVID-19 positive (controls include untested) C2_v2_england_controls COVID-19 positive (controls include untested), only patients from centers in England There's nothing different about the groups in terms of lab testing, the second one...

Ok, I see you mean that there may be less interesting reasons on the causal pathway between the genes and being a member of the COVID cohort, not so much the randomness of an invisible hand rolling dice for whether a person will or won't get COVID with no regard for what genes they have. Yeah...

And a note that the ME Research UK article posted above only mentions IL-5 and IL-3, the second of which isn't mentioned in either paper. I think it's a typo for IL-13. Edit: I let them know and they very quickly fixed it.

Yeah, I'm not sure why this review mentioned IL-5, but not IL-6 which was more significant. This is the relevant part of the study they're describing:

I think one of the most interesting parts of the study will be seeing what genes matched between these participants with ME/CFS and Biobank data on depression and COVID. Considering the similarities between ME/CFS and depression, and how the distinction for accurate diagnosis can be tricky, so...

You're saying the genes for COVID in the UK Biobank are essentially mostly random and meaningless? "Bad luck" is randomness, which is what significance tests are used to rule out. If they were split into COVID and control only or mainly based on random chance, then there should be minimal...

I think figures A and B are looking at rare variants and C and D are looking at common variants, so there should be some differences. And I think Fig. D is using genes from a specific other study (ref 38, Lammi 2023) that used data other than the UK Biobank, which was used in Figs. A and B.

I'm not sure I follow. The GWAS returned genes significant between people who have and have not had COVID. Since they're genes, they won't have anything to do with age. Maybe there are genes that affect what occupation they got, but that's still on the causal pathway between genes and getting...