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I'm happy to see that they'll be measuring IGHV3-30 during this study. We'll see if there's more confirmation that it's high, and maybe see how it relates to improvement, if there is any.

Bluesky thread from the author going over the results. A couple interesting points:

Thanks. It looks like the protocol, not results, though.

See the following relevant thread: Sweden: Have the ME and CFS clinic in Gothenburg found a loophole to avoid the diagnosis ME?

From the first citation: Quite a stark difference. Some discussion here: https://www.s4me.info/threads/coq10-coenzyme-q10.13640/post-259964

Up to now, I've mostly tried to avoid reading or posting research that involves animals, because I find the practice often is abhorrent, and I don't want to support more of it happening. Making mice fear for their life in a swimming test, injecting animals with chemicals that we would never...

Exploratory Study on Autoantibodies to Arginine-rich Human Peptides Mimicking Epstein-Barr Virus in Women with Post-COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Friederike Hoheisel, Kathrin Maria Fleischer, Kerstin Rubarth, Nuno Sepúlveda, Sandra Maria Bauer, Frank Konietschke...

Crosslinking this announcement from the ME Association thread: https://meassociation.org.uk/2025/08/the-me-association-awards-decode-me-the-howes-goudsmit-award-2025/

NEGR1 and DCC were the only two genes that were significant in both males and females (using different tests). NEGR1 and DCC also happen to be the genes closest to the 10th and 15th most significant loci in the DecodeME study (though below the genome-wide significance threshold at 1.19e-7 and...

Sex-stratified genome-wide association meta-analysis of major depressive disorder Jodi T. Thomas, Jackson G. Thorp, Floris Huider, Poppy Z. Grimes, Rujia Wang, Pierre Youssef, Jonathan R. I. Coleman, Enda M. Byrne, Mark Adams, BIONIC consortium, The GLAD Study, Sarah E. Medland, Ian B. Hickie...

Stellate Ganglion Block for the Management of Long COVID Symptoms: A Retrospective Cohort Study Michael C. Chiang • Kathryn M. Satko • Christina Shin • Beau P. Sperry • Meghan L. Cabral • Zack Crockett • Richard Gao • Robert J. Yong • Samuel P. Ang • Stacey L. Burns • Alexander J. Kim [Line...

Impressive investigation! It looks they want to appear to be working within Canadian criteria guidance, but if they are really not diagnosing anyone with ME/CFS, they're almost certainly not following the "spirit", or original intent, of the criteria.

On the other hand, we're talking about a disease where proteomics and exercise tests have already been tried several times in less severe people. If there actually are differentially expressed proteins, we expect them to probably have tiny effect sizes, and when you're correcting for a hundred...

The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers Lei Wang, Yujia Xu, Xiang Zhong, Guiping Wang, Zijun Shi, Can Mei, Linwanyue Chen, Jianbo Zhan, Jing Cheng [Line breaks added] Abstract Chronic fatigue syndrome (CFS) is a...

There were some mentions of butyrate in the NIH deep phenotyping study, and in the symposium about the study: ME/CFS Symposium – May 2, 2024 Figure S20D from the study's supplementary info seems to be about the specific bacteria in the gut. It looks like increases and decreases of many...

Yeah, my assumption of how well it would match severity was not based on much data. Just some anecdotes on the forum and knowing that severe/very severe people are known for spending virtually all time lying down. And for myself as probably moderate, I spend most of the time lying down, but I...

The Association of Long COVID and CKD: Findings from the National Clinical Cohort Collaborative (N3C) Anzalone, A. Jerrod1; Krichevsky, Spencer2; Yoo, Yun Jae3; Wilkins, Kenneth J.4; Alakwaa, Fadhl5; Liu, Feifan6; Sakhuja, Ankit7; Saltz, Joel H.8; Han, Yun9; Zhu, Richard L.10; Setoguchi...

I think this might be backwards from what I said. Since lying down includes sleeping, I thought it'd be too much math to try to add up time spent lying down while sleeping plus throughout the day. So instead it's time spent not lying down. So if you are mostly up from when you wake up at 8 AM...