Search results

I was interested in monitoring my temperature once. I bought a ~$10 mouth thermometer from the drug store. It was so unprecise. I would measure it three times in a row within seconds of each other, and it'd be a different temperature every time (I think a span of about 1°F). Maybe good for...

We have moved some posts about whether people experience fever as a part of PEM to a new thread: Do you have fever as a part of PEM?

With all due caution regarding my attempt at the MAGMA gene set analysis, I just want to note that there's a further similarity to the Zhang results that might allow us to go a bit further than "synapse" to "postsynapse". The most significant synapse related gene set is specifically...

Posted because this is from the PrecisionLife team who is also working on ME/CFS with their proprietary technique.

Identification and Validation of Novel Combinatorial Genetic Risk Factors for Endometriosis across Multiple UK and US Patient Cohorts JM Sardell, S Das, GL Møller, M Sanna, K Chocian, K Taylor, AR Malinowski, C Stubberfield, A Rochlin, S Gardner Background Endometriosis affects about 10% of...

I thought it might be useful to extend this to more loci than the top 8. Supplementary table 3 has the top 25 loci. Using LocusZoom (online software for uploading and viewing GWAS data that they used in the study), I looked up all of these loci. I combined them in groups of five in the...

Yes, though their evidence for the misrepresentation of symptoms is only the published Reme, Chalder study I quoted, and they don't say too much about this specific point. The following from NICE guidelines evidence review is almost a direct quote from the study. And this is their overall...

While the synapse-related gene sets weren't bonferroni-corrected significant in the DecodeME MAGMA test I did (which I hope to redo with the standalone MAGMA instead of FUMA so that no conversion/data loss is needed), it's striking that it's one of the top gene sets and matches Zhang's finding...

Thank you, I'm working through adding relevant quotes. This is such blatant manipulation of statistics, it's amazing: - https://lp-fortellinger.no/en/2022/02/24/venke-midtlien-2/ - https://lp-fortellinger.no/en/2022/02/24/kristin-stolen-2/

Would you count sickness response during infections as an illness? As far as I know, that's largely thought to be symptoms produced by the brain. There are some similarities with the symptoms of ME/CFS, so it might be worth looking into the biology of the sickness response. For example, first...

Previously on Qeios with two comments: Orexinergic and Hypothalamic Dysfunction in CFS/ME: An Integrative Review with a Focus on Precision Medicine

An integrative review on the orexin system and hypothalamic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: implications for precision medicine Noé López-Amador [Line breaks added] Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating...

I've come across the claim that the Lightning Process (LP) intervention, at least in some cases, includes coaches teaching patients to misrepresent or lie about their symptoms to others. If this were true, any trials of the LP which rely on subjective outcomes would be completely unreliable as...

The example locus you gave might be one of the harder ones to do this with because there are so many genes around the locus. There's a good chance the causal variant isn't the top hit, so one of the other variants near another gene might be causal.

From the link: Somewhat brilliant way to make money.

Yes, I think it could be worded better. I haven't seen anything that makes me think they limited follow-up tests to only those 13 genes.

See here (different letters used but same idea): The tissue gene-property analysis is a linear regression of all genes. Z is a gene's score from the GWAS and Et is a gene's expression in a tissue. Both of which are continuous, not binary. For the gene-set analysis (the ubiquitin, synapse gene...

Radio New Zealand: 'Genetic links found in ME/CFS patients' "New research has found myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is partly caused by genetics, related to the immune and nervous system. The study - the world's largest into the condition - identifies DNA...

Yes, combined with Zhang's synapse findings, it seems more and more likely to me that the brain is part of the picture. I can't remember if we have other reason to think about synapses specifically. Maybe your earlier suggestion of thinking about which of the genes from the top loci have an...

Let me know if you run into issues. There were a few annoying roadbumps in the process. Maybe. I imagine the eight main loci might be related to brain, might not. Maybe 6 are, and 2 are related to the immune system. But MAGMA is more like, if you average out all of the genetic signal, what does...