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It was like this for me a few years ago... I could go hiking and my pulse would be <100 even if other days I did the same thing it would be more normal and reflect the amount of work my body was actually doing. A bit like now, just the other way around :P I went for a walk with some friends, had...

I really want to do an analysis of activity trackers looking at times when steps are close to zero/zero, but we're still getting told we're doing cardio. Does it coincide with PEM for example. Right now I only have fitbit data from normal people, and am looking to see if I can find the same...

Recently there was a short debate in "Dagens Medisin" (a health journal in Norway) about antibiotic treatment vs an operation for appendicitis. One proponent started it and got a reply from a surgeon. I'm pretty sure that was about adult patients, though.

Others feel better on a 100% raw vegan diet, which I'd say is near impossible to make ketogenic. A factor in both type of diet change is it can be a pretty drastic change for the system.

Cells are stressed when they are low on energy/ATP, leading to signalling cascades to increase energy/ATP production. They found an increase of proteins involved in several pathways that can increase energy/ATP, compared to how these pathways are utilized in the control cells.

The difficulty is that it's hard to do studies on diet and these types of diseases as it takes so long for them to develop. We know from multiple large observational studies that a whole-food type diet pattern is associated with lower risk of diabetes, heart diease, being overweight and other...

A bloodsample. In this case, it was a change from a "standard" diet to a diet following that country's specific dietary guidelines (these are pretty much the same all over the world: increase intake of whole foods, fiber-rich foods such as fruits/vegetables/legumes/grains, eat high quality...

Glutamine and glutamate can be drastically altered by dietary changes in otherwise healthy humans (I've seen around 1.5 fold increase in glutamine, with a similar reduction in glutamate, by changing diet alone), and reduced glutamine with increased glutamate is seen in many conditions.

What do you mean by "sensitive to proline", sensitive to the amount we get from a regular diet or some supplement?

When I crashed three years ago (still haven't recovered from that one) I could gain 4kg in a week, and then drop it the next week. I still get water weight when I crash, but not as much (I guess it has to do with losing muscle over the last three years).

I remember my mother (previously worked as an ICU nurse) commenting on my skin saying she would be very concerned if one of her patients had looked like that o_O I don't think my sometimes blue/purple skin is in my records, but it's also something I had before I developed ME and something I kind...

I've been thinking a lot of dyspnea lately, mainly because I've felt like I can't breathe properly. I don't have it all the time, and it worsens with PEM. My breathing is more shallow, but I don't know if it's like that all the time and I only notice when I crash - or if it happens when I crash...

The quality of the evidence has been highlighted in Norway, can't say it has helped any. Unfortunately.

A number of posts discussing the difference between PVFS and ME/CFS has been moved to a new thread, "When is post viral illness PVFS and when is it ME? Discussion." that can be found here: https://www.s4me.info/threads/when-is-post-viral-illness-pvfs-and-when-is-it-me-discussion.19120/

I'm happy for a prospective study, and hope we get some good data from this, but I have to agree with @Esther12 that a history of misrepresenting results is worrysome.

Too tired to read and comment now much now, but if they are calling zonulin a tight junction protein that is not correct. Zonulin can regulate TJP expression and organization at the cell membrane, but it is not itself a TJP. It's produced many places in the body and is associated with various...

A least in Norway ME is not mentioned much in our studies. We will have one lecture about ME in pediatric patients two weeks from now, but that is only because there's a local doc that works with the patient group giving the lecture. When I had about adult patients it did not come up. CFS (not...

I get nausea and lose my appetite when I crash, my GP has never taken much interest in those symptoms except when I've expressed worry about losing weight. I'm training to become a dietitican, and once when I was interning at the hospital we had a patient that had had diarrhoea for five years...

I find PCA score plots easier to interpret than TSNE plots, but yes non-linear relationships might work better with TSNE (I've never used TSNE, just read about it and decided on PCA as it was less costly and worked well with my data). Is it possible to do a supervised version of TSNE?

Why TSNE and not PCA?