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Given for ME, and therefor presumably for SEID too, onset is associated with a variety of triggers is PPBL just another such trigger? Might it turn out that ME and/or SEID is more common in other conditions than previously recognised? (Have any studies been done on the overlap between SEID and...

Boosters may be needed for two reasons, one to boost the effect of the initial vaccination which wears off over time, and the other to modify the the resultant immunity to include new variants. The length of time the vaccine induced immunity lasts varies between different vaccines/viruses, from...

There are arguments about its origin, but one explanation is that a number of property deeds were sent up to London hidden in a pie as a bribe for the King to stop the destruction of the super wealthy Glastonbury Abbey and the seizure of all its land. This version goes that the bribe was...

Is there a research project to be found here looking at how accurate different researchers are at identifying whether what they pulled out is in fact a plum, rather than something else completely different? [Is it also apt that the original nursery rhyme is about a property swindle in...

I initially misread this study as relating to ‘experimental avoidance’ rather than ‘experiential avoidance’, and thought perhaps it was specifically addressing differences between Gulf War Veterans who did and who did not want to participate in research. Certainly with ME I would expect a...

I am assuming this investigation of the corneal nerves is because it offers noninvasive access to the nerve fibres/dendritic cells rather than suspecting a specific ocular disease process, which makes it potentially a very useful tool. It would be interesting to see this replicated with a range...

It doesn’t, but I suspect we are still at the stage where it is believed that any health professional involvement will result in improvement, so multidisciplinary involvement will result in even more improvement. Thinking of something that can be tried is unhelpfully seen as the same as having...

This is pure speculation based on just eyeballing the graphs, but … It is possible that reduced prescription of opiates, results in fewer deaths associated with prescribed opiates on the basis of these graphs, though I have no idea if the apparent relationship is statistically reliable. However...

At times when my ME has been relatively mild, I find I can get quite high in situations where I find myself able to engage in unexpectedly increased activity levels. I have learned now to be cautious when in that state. However once in the Falklands I ended running up and down ‘mountains’ with...

I find I often forget I want to go to relatives’ weddings, godchildren’s graduations, family funerals and so on (sarcasm alert); does this person even read what he has written. He is setting people up for failure, for anxiety and depression. Let’s undo the decades of coming to terms with a long...

Though OI interacts both with ‘fatiguability’ and PEM, I think the fact that we can see PEM triggered by cognitive activity would suggest that there is no simple equivalence between OI and PEM, as for some people at least it is possible to trigger PEM without being up right.

Whereas historically with ME it has been studied by looking at the least ill.

You may be right @Invisible Woman, but I wonder if increased fatiguability is a symptom of the ME, and a contributory factor to triggering PEM, though distinguishing the two will complex as once PEM is triggered fatiguability is increased even more along with the other ME symptoms. My reason...

I agree with this distinction. PEM as described by @alktipping is a diagnostic feature of ME and of some at least with Long Covid. More rapid fatiguability occurs in many conditions and is significantly different to what people with ME understand by PEM. Having said that it is worrying that a...

From the India Today article:

Not only that, but a significant percentage actively made the choice to lie down prior to dying. So obviously their death is a symptom of an underlying functional disorder, and consequently the best response is to undertake a specially developed course of CBT for those that are functionally dead...

Over such a short time period, when the patient is knowingly focusing on their ability to increase their tolerance of physical exertion, we have no idea if improvement of a six minute walk test represents a genuine overall improvement or a focusing of activity to allow more investment in the...

Even if these results represent meaningful correlation there are so many alternative possible interpretations. My personal favourite is that the worse an individual’s condition, the less likely they are to swallow a nonsense MUS diagnosis. Someone with a very slight limp my be happy to accept...

Interesting but like @Trish indicates it looks like three individuals are contributing a lot to the heavy lifting. Also it would be interesting to have data from other comparator groups, as even if the association is robust, it would be good to have more confirmation about the possible...

My GP practice has just shared the following on opting out of planned data sharing/marketing: