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Good point. It’s very different from the flexibility and humility of changing when information changes and admission of being wrong, which I think we would all welcome and which would serve everybody in this situation better. The desire to be ‘right’ and protect one’s ego is very common, being...

It’s entirely about that isn’t it, what they’ve emotionally invested in this idea. Because if you’ve got that much of a reputation, the positions they have, isn’t it wiser to just admit what is in front of you and move on? Why bang this drum, it makes no sense. It also shows a real inflexibility...

I suppose we could call our condition Mornington Disease or maybe a study into it the Quatermass Xperiment?

Jonathan is obviously better placed and more qualified to respond. But IMHO it could be but it may not. I doubt they’ll be anything quite as clear and simple, more lots of little things here and there which may slightly shift the balance in favour of whatever is going wrong to happen. Like a...

From the above Then from another mouse model paper https://pmc.ncbi.nlm.nih.gov/articles/PMC4749920/ So decreased BTN2A2 means increased interferon gamma from T cells?

They should also understand correlation vs causation, good study design, how to read a scientific paper and Bradford Hill criteria … and yet

Sounds to be like they’re anxious about their reputations ;)

Great work @Trish “Prof Alan Carson makes an unhelpful comment” is evergreen

They’re not having any of our cake! Or perhaps the cake is a lie…

The above link has now been updated with audio of the full paper. It’s not perfect, there’s some funky bits of pronunciation but I don’t want to spend too much more time tweaking. I also think it’s written in a very accessible way so is quite listenable. That said I’ve not listened to the...

If I didn’t have such bad reactions to the vaccine I’d be seeking how to get it. As I am trying with the flu vaccine. It does seem a little nuts that people who want to get vaccinated can’t get. I suppose one argument is they had huge piles going to waste because the public chose to stop having...

The framing by the Telegraph criticising Labour for a decision made by the JCVI months ago seems a little political…

Presumably, full genome analysis including rarer variants could not only find other genes not looked at yet, but those genes could have a higher contribution/effect size? A few rarer variants working in conjunction with these more common ones could give clearer information on pathways involved...

https://www.bbc.co.uk/sounds/play/m002gqy1 Skip to about 2h 36m in

Straight after the news, good spot, a personal story from a young woman describing what so many have experienced from the medical profession followed by an interview with Chris Ponting. Questions on auto-immunity, medical misogyny, Chris focuses on his message well. And the interviewer is to...

No mentions of SUDS3 or SDS3 on the forum as yet, however Other mentions of HDAC1 on the forum https://s4me.info/threads/increased-hdac1-expression-increases-mitochondrial-dysfunction-in-endothelial-cells-2022-jones-et-al.27625/latest...

Nothing from the BBC website yet, hopefully there will be as it has huge reach, but looking at all the other headlines from search engine news feeds the message seems good, this is what the casual observer or half interested person will probably see. Great job by the whole team in getting the...

Looks like some great reporting, a few hiccups and the usual suspects trying desperately to remain relevant. If only they’d shown such skepticism and caution around PACE and the theories they’ve been pushing for decades. Can’t imagine why there is such a difference in tone. I’m sure there’s no...

Just wanted to echo all the thanks and congratulations to everyone involved in the project. But also say what a great blog post this is from @Simon M and thank him for it. I’ve been able to share it with lots of people I know who aren’t deep into ME/CFS, science or even that aware of DecodeME...

Other s4me threads mentioning this gene https://www.s4me.info/threads/genome-wide-association-study-of-multisite-chronic-pain-in-uk-biobank-2019-johnston.44973/