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The trial seems to have been conducted by SetPoint who make the device, here’s their PR. Are we thinking this is a complete waste of time or perhaps having a marginal effect somewhere, maybe downstream rather than directly modifying immunology? What are the questions over the study… Would the...

I wasn’t sure where best to put this buy while looking through some audiobooks at my library I came across the book “Dirty Genes” by a Dr Ben Lynch a partial description of which is: Full description here. The author has a website and a bio which can also be found here. In short he’s a...

And you could probably argue that one of the reasons PACE was ‘successful’ was the messaging (as well as support from influential people). If we can combine good science, evidence and a good message that seems to me more likely have success than just relying on the science. I know some...

Agree. It’s amazing what is impossible until it becomes possible. And thanks for raising this example. Although I understand these points have been made it’s really helpful to have counters/examples to the common talking points those of us who are in contact with MPs and government departments...

I did my own versions of a lot of what visible does earlier in my ME/CFS journey (logging activity, tracking steps, heart rate, hrv, etc) but stopped. What I learned was useful but as an ongoing thing it wasn’t. I also have some concerns over visible themselves. These sort of companies usually...

It’s very common for all sorts to go out on the last day(s) before recess. Not a good practice, but a common one.

The name may be off putting but such is marketing. The technology looks like it could be interesting and has apparently shown promising results An article on a phase 3 trial for an Alzheimer’s drug https://pharmaphorum.com/news/roche-preps-phase-3-brainshuttle-alzheimers-drug And relevant...

One aspect I’ve wondered about is simple awareness. Are there are ways of us getting the message out about DeocdeME to medical schools/universities (I have a teaching hospital, medical school and universities locally to me for instance). Not sure how well this would be received and it’s not the...

I seem to remember one trial run over recent years which showed Eliza performed better than modern (this was a few years ago) LLMs in fooling people that it was human. Perhaps that was the start of some of the extra sycophancy of more recent models styles?

It is really difficult to understand the motivations, for anyone else, but specifically in this case. We can guess but given the structures and politics probably impossible to know, but it does seem clear something is blocking things here from what so many say. I wonder if things will shift if...

The PTerminator? Can we add in some robotic CBT… RoboCog?

I had to reply as this whole post deserves more than a thumbs up. So well put @bobbler

Nice! :)

Some SNP lookups tools I found today which may be useful too https://www.ncbi.nlm.nih.gov/snp/ https://snpedia.com/index.php/SNPedia For instance here’s the info for rs76346913 which was referenced in...

I’d tend to agree. There’s a few areas where reviews seem to be being put into place in the hope it will be easier to do what they want or know they need to do once the review reports. It’s not pretty and is pretty wasteful in itself. But that’s politics.

Blue zone forests perhaps? Can we get funding for a qualitative study of which forests promote the most wellbeing? It may involve travel to some rather nice locations… Edit: for those that aren’t familiar, just search blue zones and see the amount of weight the idea is given then read this...

I’d echo this. Stick to asking questions that are basically explaining a word or term, ideally after giving some context or source material, that way the models are usually regurgitating definitions from elsewhere. And if you ask about and prod the same topic from multiple angles over a week...

I suppose equally you could say that the entire root cause of a running program is it’s entire running code, memory and the environment itself running in (including most importantly every input received). A dump will show you the entire state at a given point, which sort of allows you to...

Thanks for highlighting this @forestglip , I hadn’t seen it and have just listened to a summary. It’s particularly interesting having recently spent time going through the Data Analysis Plan for DecodeME a few times (which I really recommend anyone who can does). Seeing all the long, methodical...

It also sounds as if different receptors are involved according to this Wikipedia page on cholecystokinin antagonists Which sites this article on cholecystokinin (only a summary of each section is available but it looks interesting)