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  1. ME/CFS Science Blog

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome', Larun et al. - New version October 2019 and new date December 2024

    Does anyone have acces to the 2024 version? Has anyone checked if it is the same as the 2019 one but with the editorial note added to it?
  2. ME/CFS Science Blog

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome', Larun et al. - New version October 2019 and new date December 2024

    It seems that between 2019 and 2024 there was no new publication of the same review. So for the editorial note that explained that the 2019 review was being updated, they did not published a new version. But to announce that this updated is cancelled, they did?
  3. ME/CFS Science Blog

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome', Larun et al. - New version October 2019 and new date December 2024

    New versions of the review were published when the authors responded to some of the feedback and comments. On PubMed I found the following versions of the review by Larun et al. (the first two versions of this review were by a different author team, namely Edmonds et al. in 2001 and 2004)...
  4. ME/CFS Science Blog

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome', Larun et al. - New version October 2019 and new date December 2024

    To clarify myself: I can see the abstract and summary of the 2024 version of the review but not the full text. I do not have access to download it. I was wondering if anyone else have access to check if it is indeed the same as the 2019 but with the editorial note added to it. In the latest...
  5. ME/CFS Science Blog

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome', Larun et al. - New version October 2019 and new date December 2024

    Does anyone have access to the 2024 version? Am I correct to think that the latest search of the literature took place in May 2014, so more than 10 years ago?
  6. ME/CFS Science Blog

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome', Larun et al. - New version October 2019 and new date December 2024

    I don't know what is standard practice at Cochrane but it does seem that previous editorial notes did not result in a new publication of the entire review. For example the previous note about the update in 2020, did not result in a new version.
  7. ME/CFS Science Blog

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome', Larun et al. - New version October 2019 and new date December 2024

    Looking at the version history: does seem like it was just about the editorial note as @Yann04 said:
  8. ME/CFS Science Blog

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome', Larun et al. - New version October 2019 and new date December 2024

    The comments are still there from what I can see, so linked to the 2024 version. You mean this one? I think it is rather confusing to republish the review if nothing else changed. On Pubmed for example, you don't see the note so people will likely think that the review received an update in 2024.
  9. ME/CFS Science Blog

    Preprint Safety, tolerability and clinical effects of BC007 on fatigue and quality of life in patients with post-COVID syndrome (reCOVer)..,2024,Hohberger +

    Assuming that the text is correct and sequence A got placebo at visit 8, then it is strange that it outperformed sequence B (which received treatment) after the crossover on the Bell scale. Here's a visualisation of that. After crossover the placebo group seem to have performed better? This...
  10. ME/CFS Science Blog

    Preprint Safety, tolerability and clinical effects of BC007 on fatigue and quality of life in patients with post-COVID syndrome (reCOVer)..,2024,Hohberger +

    The text is rather confusing. They write: 'Sequence A received 1350 mg BC007 followed by placebo, sequence B received placebo, followed by 1350 mg BC007.' But then they start comparing the sequences ("no statistically significant differences between sequence A und sequence B were observed")...
  11. ME/CFS Science Blog

    Petition: S4ME 2023 - Cochrane: Withdraw the harmful 2019 Exercise therapy for CFS review

    The email by Cochrane to the authors states states: Would be interesting to read what was said and what the arguments agains the new review were. Would this be possible to request using FOI?
  12. ME/CFS Science Blog

    Preprint Safety, tolerability and clinical effects of BC007 on fatigue and quality of life in patients with post-COVID syndrome (reCOVer)..,2024,Hohberger +

    The primary outcome of treatment-emergent adverse events (TEAEs) was as follows: So although the difference was not statistically significant (due to low sample size and rate of events), there were more than twice as many adverse events in the intervention than in the control group. If I...
  13. ME/CFS Science Blog

    Petition: S4ME 2023 - Cochrane: Withdraw the harmful 2019 Exercise therapy for CFS review

    Before 2019 ME/CFS patients simply pointed out problems with the Larun et al. review and asked for these to be corrected or withdrawn. As far as I can remember it was Cochrane itself that came with the initiative of writing a new review using a new protocol. Here's what they said in 2019: So...
  14. ME/CFS Science Blog

    Trial Report Effectiveness of a brief multicomponent intervention to improve physical activity & functional capacity in FM & CFS (Synchronize+) 2024 Martín-Borràs+

    They don't seem to report any between group difference and tests, only within groups? That approach is usually a sign that the results were not what they wanted them to be...
  15. ME/CFS Science Blog

    Trial Report RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2024, Cash et al

    I assumed nobody would take these results seriously as indicating a real effect but Suzanne Vernon wrote on the Bateman Horne clinic website: https://batemanhornecenter.org/promising-clinical-trials/
  16. ME/CFS Science Blog

    Trial Report RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2024, Cash et al

    Yates's correction for continuityQuite a few patients scored a value of 0 at baseline or follow-up which seems weird given that these were the completer's analysis, so 0 doesn't indicate missing data. The abstract writes: 'A greater proportion of subjects in the oxaloacetate group achieved a...
  17. ME/CFS Science Blog

    Preprint Increased physical performance and reduced fatigue after personalised physiotherapy and nutritional counselling in long COVID, 2024, Jimenez Garcia

    The intervention arm included dietary advice and symptom-contingent exercise. They write: "A symptom-titrated pacing strategy was implemented to account for exercise intolerance or PEM." The control group received standard physiotherapy. Unfortunately, it seems that there were no significant...
  18. ME/CFS Science Blog

    Trial Report RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2024, Cash et al

    Had a look at the data and the group difference was 0.81 [95% confidence interval: -1.32 to 2.94], with a t-test p-value of 0.449. The cohen d effect size is 0.19 [-0.30, 0.68]. So nothing to see here unfortunately.
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