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This is a historic paper from 1993 where POTS was first defined. I am very interested in reading what it says but do not have access to it. Anyone who can share a copy with me in PM?

Abstract To characterize the idiopathic postural orthostatic tachycardia syndrome (POTS), we reviewed the records of all patients aged 20 to 51 who presented to the Mayo Autonomic Reflex Laboratory and who exhibited tachycardia at rest or during head-up tilt. These patients were usually women...

Yes that is another big problem. But I meant something differently: a study that does tilt table testing in a representative sample of the general population to see how well POT correlates with OI and other symptoms.

The supplementary file gives the following data (my bolding): Head-up tilt table testing at 70 degrees from horizontal for up to 40 minutes was performed during which finger blood pressure (BP) was monitored continuously and upper arm blood pressure measured with a cuff every four minutes...

This paper looks to be important for the origin of the concept POTS: Schondorf and Low labeled the condition “idiopathic postural orthostatic tachycardia syndrome” in a series of adults, suggesting the cause was “a mild form of an acute autonomic neuropathy” Schondorf R, Low PA (1993)...

Thanks for sharing. It would be interesting to have data on tilt table testing in a large representative sample of the general population to see how well POT correlates with POTS symptoms. Does anyone know of such as study?

There author makes three interesting points about POTS in adolescents. The threshold for standing test should be lower than for a tilt table test because in the former you're still actively using your leg muscles to stand, promoting venous pumping. An increase of 40pm in adolescents is not...

It's also a strange thing to study: whether making up an explanation for symptoms makes the patient feel less ill. I assume that the main message from this paper is to tell doctors that it's ok to use some made-up explanation for symptoms they can't explain. It's not only allowed, it's now the...

Apparently, the symptoms are no longer medically unexplained. That seems to be the main message that they want to spread. In the introduction the authors write: "People with persistent physical symptoms commonly have poor experiences of health care8,9 and are often told that their symptoms...

This is the primary outcome, the PHQ-15

Another flaw: just noted that the statistical analysis section says: "...no adjustments were made for multiplicity."

Looks like a highly problematic study. It has the design A +B versus A. The control group got no intervention at all, only the usual care that the intervention group also received (in addition to the intervention itself). Patients and GPs were not blinded and they only used a subjective...

A critique of this study was published by Paul Garner, Alan Carson and others (but also George Davey Smith). They write: There are problems with the methodology in this study. Firstly, the authors use levels of CRP relative to other biomarkers to make a large number of possible ratio traits...

The definition seems to be overly inclusive. It does not require any particular symptom, does not require any level of functional disability or impact of symptoms on activity levels, does not require proof of Sars-Cov-2, etc. It is just a list of 'can' and 'may'. Almost everything can fit that...

Now that I think about this, there is probably an easy way to test this. The mean of 'Reward_Granted_Yes_is_1' is 0.48 and if I take the mean for each of the probabilities of reward it looks like this. So yes I think this variable does not take successful completion into account and simply...

In the experiment, participants had a chance to receive a (virtual) reward in each trial round if they were able to achieve the required number of button presses. This was a requirement but they did not get it each time they achieved the required number of button presses. There was also a...

I was only able to skim it briefly but it looks like a good blog that identified many of the same issues discussed here on the S4ME thread. One issue that has the title 'False Recording of EEfRT Data' was new to me. Burmeister argues that there are errors in the raw data because the value...

Don't think this review from last year has been posted yet on S4ME. I noticed that it was used as a source in the NASEM report on Long Covid to claim (on page 167) that: "Rehabilitation can improve functional outcomes in people with Long COVID, regardless of the severity of disease or duration...

Abstract Importance: Current rehabilitation guidelines for patients with post-COVID-19 condition (PCC) are primarily based on expert opinions and observational data, and there is an urgent need for evidence-based rehabilitation interventions to support patients with PCC. Objective: To...

This study does not have a direct relation to ME/CFS but it thought it was interesting as a criticism of the term 'functional' for symptoms of nausea and fullness. In short, there is a test where they can measure how fast the stomach empties and patients who have abnormal results for this test...