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Any update on the letter regarding effort preference and EEfRT? Has a summary of the issues identified here already been sent to the NIH researchers? @andrewkq @EndME

Thanks for the explanation @MelbME although I must admit that I still don't fully get it. If the problem is the large variation in mice behaviour, then I don't see how pooling the patient IgG into 3 groups would help to solve that. One might need a lot of mice and measurements to balance out...

Can anyone explain why they pooled the IgG per subgroup? I would think that you get the most information if each participant's IgG was given to a separate mouse (if this is possible). Because that is the interaction that you want to test for with as many independent observations and their...

Some of the figures such as figure 5 above note that they used 'BH adjustment' - so Benjamini-Hochberg adjustments. Unfortunately no exact p-values or effect sizes are given. In this study they used a control group, so it's quite interesting that their antibodies did not have the same effect...

The data on mechanical and heat sensitive in the mice seems to have the clearest effect (shown in figure 5 below), one that was present even if you ignore the subgrouping they used. The effect on immobility and locomotor ability was only present in one of the three subgroups on day 1 (not on...

Patients reported no significant improvement in pain, sleep or fatigue over time.

For diagnosis they recommend the IOM, CCC or NICE criteria. For PEM they recommend the PEM section of the DePaul Symptom Questionnaire PEM section. For anxiety they recommend the Generalized Anxiety Disorder 2-item (GAD-2) which asks two questions: Over the last 2 weeks, how often have you...

Great. Is there a blog article about this information that can more easily be shared with researchers? Many thanks in advance.

But in their earliest descriptions at the end of the 1980s they constantly refer to ME and mention exercise intolerance. Their main target was to challenge the advice of the ME associations that advocated pacing. For example: Postviral fatigue syndrome: time for a new approach - PMC (nih.gov)...

Looks like the first big study that measured ME/CFS following COVID-19. It is based on a massive amount of health records from 8 countries (the UK, US, Korea, The Netherlands, Norway, Estonia, Spain, and France). They had data on 35 million people. 3 million of those got COVID-19 and 4 million...

Interesting comments. But the proponents claim that it did work in strictly defined ME and in the PACE and all the other trials they set up. They see recovery in the exact same patients that failed to show any objective improvement in fitness or work capacity. Also if you trace back where the...

But if this was the case wouldn't we see better results in objective outcomes in GET and CBT trials?

They used a veterans database where only 10% of participants were women. Long Covid mostly affects women so probably not an ideal cohort to test long-term sequelae.

Quote from the article: "Ellis noted that the goal is to diagnose and treat people within primary care, without referring to a rheumatologist. This is not because rheumatologists don’t want to see these patients – they may be happy to – but the goal on a national level is for people to be...

Tweeted some quotes from the article and radio-program: 1) “Being in those kinds of thoughts is what’s maintaining your symptoms.” The BBC did an investigation into the Lightning Process, a controversial 3-day training program. This is what that ME/CFS patient community had to deal with for...

Bit frustrating that they don't provide a clear overview of the all the predictor variables that were tested.

Do you have any further references for this? I remember a couple of studies showing that approximately half of cases sent to ME/CFS tertiary centres did not fulfil ME/CFS criteria. But I don't think the GP's diagnosed these patients with CFS, it were patients suspected of having ME/CFS. But...

The ME/CFS pledge for the European elections We, at the European ME Coalition (EMEC) call upon candidates in the European elections to commit to supporting individuals suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) by endorsing our pledge. Those who have signed the...

The Jason et al. estimate of 0.4% was for the Fukuda CFS criteria so it seems that self-reported CFS is much higher than actually meeting CFS criteria. It is still a bit unclear to me how this is possible, given that most of the 0.4% were undiagnosed. It would be great if a study could help...

Twitter thread summary of the preprint: 1) Interesting new study from Canada from the research team of Luis Nacul. The authors recruited participants from ‘CanPath’: a population-based cohort that includes data from over thousands of Canadians. 2) In 2016 19,145 of these participants...