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Here's an English translation of what she said in Dutch during the webinar. Martje Bos: "We conducted research in Lifelines. That's a population cohort in the northern provinces of the Netherlands where, among other things, the symptoms of ME/CFS are enquired. So it asks: do you suffer from...

From what I understood, the lifelines estimate was based on how prevalent ME/CFS was among relatives of ME/CFS patients.

Apologies, the last one should have been 'without ME/CFS'.

The researcher mentioned above was Martje Bos, who is a ME/CFS patient herself and is studying ME/CFS in relation to other functional syndromes such as IBS and fibromyalgia. Another researcher, Cindy Boer said that she is leading a new major collaboration: ‘Genetic epidemiology of ME/CFS’ that...

During the ZonMw conference on the Dutch ME/CFS research program yesterday, one researcher said that they estimated the heritability of ME/CFS in the Lifelines cohort at 43% [34-51] - findings that are still to be published. This post has been copied and subsequent posts about a planned Dutch...

Post copied and subsequent posts moved from Genetic Risk Factors of ME/CFS: A Critical Review. Joshua J Dibble, Simon J McGrath, Chris P Ponting. 2020 During the ZonMw conference on the Dutch ME/CFS research program yesterday, one researcher said that they estimated the heritability of ME/CFS...

Seems like a useful paper that identified many of the problems with the popular Chalder Fatigue Scale, that have been mentioned multiple times here on the forum. Some quotes from the paper: One challenge relates to the initial instruction: ‘If you have been feeling tired for a long while...

The results were similar 1 year post CBT compared to 6 months post CBT. Unfortunately there was no longer a control group, the authors write: "For ethical reasons, patients randomized to care as usual were offered CBT and could therefore no longer serve as a control." In previous CBT and GET...

What do they mean by the following? "the Glu (p=0.017) level was only significantly higher in ME/CFS after adjusting for multiple group comparisons" Also weird that Long Covid patients had a strong negative correlation between physical function and Glx, while in ME/CFS patients there was a...

Do they report the percentage for POTS and OH separately? Couldn't find it in the paper.

Interesting analysis. Many thanks to Peter for doing all this research, I found it very useful. Might be good to write it down into a blog post that is a bit shorter and easier to digest so that it can reach a wider audience.

In the methods section on page 19 in the paper: "...Finally, the participant learned if they have won, based upon the probability of winning and the successful completion of the task. This process repeats in its entirety for 15 min. "

I might have misunderstood, but the article is a bit difficult to follow for me: first it suggests that one should measure not only the presence but also the severity of symptoms and then it argues that a reduction in functioning should not be required in case definitions. I would argue that...

'A pre-determined reduction in functioning should not be required to have long Covid' I disagree with this and think it is one of the big problems with Long Covid case definitions in research: they selected people with symptoms that had relatively little impact on their functioning. What is of...

This is what I got for the GEE modelling with the 3-way interaction: model_formula = "Successful_Completion_Yes_is_1 ~ Sex_Male_is_1 + Value_of_Reward + Probability_of_Reward + Trial + Expected_Value + is_patient + Trial * Trial_Difficulty_Hard_is_1 * is_patient" Taking the results for the...

My initial guess would be to ask for 2016 anyway: if it is too large, perhaps we could filter it ourselves but then at least we have the info. But I don't have any experience with these things so happy to hear what others think.

Thanks for pointing this out and apologies for the typo about the p-value (I accidentally wrote 0.41 instead of 0.041). So when taking al trials into consideration in the GEE modelling, the results are quite similar so I don't suspect anything fishy here. I'm still not quite sure what they have...

I also don't see missing data, HVA has data for all trials in my dataset. Perhaps an error with uploading or something like that?

No problem, I think it is very useful to have more people like you with a statistical background on the forum. I hope you will stick around!

Yes, I could try to help a bit (depending on how much info they send and how feasible it is to go through it).