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I don't really know much about either

How would one test this hypothesis? Is it something that can be measured somehow or would it be a therapeutic experiment? Do you mean several different ME/CFSes or different diseases like ME/CFS, narcolepsy and cataplexy all sharing the same mechnism?

Do you have any idea what it could indicate?

This thread has been oddly reassuring as I thought it must just be me!

Interestingly i began to have paralysis episodes when I was still mild but beginning to deterioate a bit, but only in very bad crashes. Much more frequent now of course. I get the dystonia too. What makes you speculate that it is a key feature?

Just anecdotally, I have episodes of temporary paralysis when I crash, and I know others do too. My partner who is also a pwME has episodes where she falls asleep very quickly in the daytime that do not feel to her like the regular feeling of getting sleepy and taking a nap. She has never been...

How bizarre - I found the T cell one, thought it probably wasnt that, looked further, found the autoantibody one you linked and then accidentally linked the T Cell one instead! I suppose I had both tabs open. Damn brain fog!

Ah - I assume you mean this one:

Is this in a published paper or forthcoming?

He claims its in a paragraph near the end of a paper, not sure which one. So i guess no data are provided. Yes I'm aware r.e. health rising, I was more wondering in terms of Lipkins claims about his work than any editorial spin that might have been put on it.

Lipkin mentions a 1999 finding of antibody titers to 'all sorts of things that are not even found in nature' @Jonathan Edwards isn't there something in your hypothesis about antibody response to 'junk' antigens? This bit... What do you make of the claims Lipkin makes that are quoted in the...

So does Lipkin have a history of these statements like Klimas does? Or is this out of character and therefore a little more believable? Of course he is trying to get his funding turned back on, so who knows. But it does seem we are seeing more and more of these statements...

Does Daratumumab have a similar effect?

I saw Moreau talk about this in an interview recently, didn't know Fluge and Mella were involved though. Very interested to know what others think. Is there a word missing at the end here? I can't quite parse it.

It is bizarre how little transparency there is for such a large and expensive project. Or perhaps it isn't...

While I think the grouping of mild moderate severe and very severe are broadly valid, I do think the words should maybe change. Mild ME/CFS entailed cutting down on most of my socialising and hobbies, not being able to work full time, regular spells of being so ill I couldn't easily leave the...

Seems like this could be really vital for LC research if they select/stratify cohorts properly.

So they pivoted to WGS then. Am i right in thinking it's more sensitive or specific? I remember Chris Ponting posting something showing the evidence of combining both WGS and GWAS.

Ah right. Whole genome as well my brain foggy mind thought it read GWAS. Why haven't they done a GWAS? It makes no sense to me.

Yes I heard rumblings about this happening a little while ago? Took them long enough. Anyone have any solid info?