Search results

I think the difference is in our perception of how likely basic science is to produce a result. Surely we feel that good science done methodically is likely to produce a result that will lead to treatment. Whereas trying random drugs is much less likely to. Otherwise why are we all here?

If your theory is correct, what kind of treatments would we be looking at?

From reading a lot of the patient stories and hearing what the researchers say it seems like some people benefit a lot but most don't respond or not much. So it could be that when the full study is published we see big responders and non responders averaging out here. Or it could just be placebo.

Posted at the same time! I caught the 3d muscle seminar, inadequate summary above.

Watched the 3D muscle presentation. To my layman's ear it all sounded absolutely facinating. They seemed to have found loads of significant differences in how the muscle responds to ME and LC serum compared to controls, and also in gene expression. Obviously I'm not a scientist but I think this...

The only genetics paper i remember is the SIPS one from a very small number of patients. No capacity to hunt it down now apologies.

That seems like a worthwhile project in terms of replication. Beyond frustrating that funding has been pulled. I hope that the government sees sense but not holding my breath. Perhaps there are alternative funding sources that could be explored, as discussed in the SequenceME thread?

Can you say whether the planned GWAS collaboration with Lipkin/Columbia was going to be in ME or LC?

Yeah I've gotten muscular PEM symptoms and joint soreness from mental overexertion on many occasions.

Or in our pockets!

Oh right yeah I guess that isn't immune mediated in the same sense. Although to be fair that lot are if anything overly optimistic about finding a drug.

I guess I'm just not sure how this disease could NOT involve the immune system in some way. Considering the symptoms and the fact it seems to usually be triggered (and often worsened) by infection.

That is what I had heard regarding new drugs, but then I had an exchange with Jonathan last year where he laid out a 'reasonable best case scenario' of how a finding in DecodeME could lead to treatment...

I'm not sure what your argument/rationale is for posting this? Is it just general doomerism? Or is it about whether the Norwegian approach vs finding drug targets first is better? Because I do not see why there should be a binary here. It is perfectly possible to believe the Daratumumab trial...

thank you, appreciate it

He mentioned planned drug trials in another interview a few days ago too.

I think the interview quoted above shows both what makes O Sullivan a paticularly ghoulish example of the BPS cult and also how she exposes their weakness more than say, Alister Miller or Simon Wessely. O' Sullivan nakedly and unashamedly lays out just how wildly expansionist psychosomatic...

Does anyone know the status of: Wes Elys Baricitinib trial The DOD Bezisterim trial Paul Hwangs WASF3 work With regard to funding in view of the recent cuts?

I've missed the chance to sign up to this, is there any info about whether the talks will be put up online? Very interested in the artificial 3D muscle talk.

I'd just like to bump my question from a few days back considering possible tgf-beta link in the fibro paper from today and general tgf b talk that's going on atm. To put it more clearly than I did above, is there a way of pushing for a larger cytokine study that could replicate this paper, if...