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If this replicates previous findings and gels with the emerging picture as @Jonathan Edwards says, is there a way to get the ball rolling on the larger cohort cytokine study? Is it something patients could crowdfund? What about charities? Or wealthy donors? It seems like it could be important...

I hadn't even considered that Edinburgh might be affected! DecodeME and LOCOME are UK funded, so this must be something else? Maybe they were planning on working with Edinburgh on a US LC or ME GWAS? I know Ponting recommended it in his research roadmap presentation a couple of years back. Or...

That is absolutely criminal. If that follow up had been done we might have had a head start on understanding ME and therefore long covid by 2020.

Was this ever replicated or followed up on? Apologies for confusingly quoting it, brain fogged today and my formatting is suffering

Very well explained thanks! So is it just lowering the odds of long covid, as being vaccinated seems to? Or is it protective in some other way?

Wessely is chummy with Jon Ashworth and of course came to prominence during the Blair years so its perhaps not surprising that the government seem to be following the BPS 'acknowledge it but play it down and publically fence sit on whether its physical or mental whilst acting like is mental'...

Interesting! Thanks for digging that up! P.s. do you mean 'presenting proteins' or 'preventing proteins'

I can't see where it says the drug is Anakinra

Have PrecisionLife said what the protective genes they think they've identified in ME/LC are? It would be so interesting if HLA-A*03 was associated with them

I look forward to reading it when it's published! And to the discussion on here which always helps me make sense of scientific papers.

I am pretty certain this is what happened to me. At 19 I developed a sleep disorder, depression, DPDR, blood sugar issues, lost my youthful energy, and experienced lots of strange unquantifiable neuropsychiatric symptoms and frequent debilitating panic attacks. All this taken together had a...

This is intriguing! Do you plan on posting this framework on here or will it just be shared within the research community at present?

The other thing I've just thought of is we need to figure out why some people who are severe for years improve back to moderate/mild. I would be so interested to see a study that compared deteriorators and improvers against the original cohorts from this study.

I have emailed Dr Cliff today, suggesting that she repeat her experiment on a cohort of people who were mild for years before deteriorating, as they may provide clues as to what is changing between mild and severe ME, and why the finding doesn't replicate in severe. In the email I also argued...

I know what you mean! I sort of feel like that but perhaps it is an irrational feeling? Plus safe is a relative term in medical drug lexicon. A lot of stuff can be 'safe' but have quite unpleasant side effects.

It also says on the information about the MELO study page 'This is a low-risk study with no intervention or treatment. Sample collection, using a cheek swab, involves minimal to no physical risk and no research related injuries are expected.' Which is interesting considering they are talking...

That sounds like good news! Missed that bit. Hopefully they can publish something soon.

Just wanted to highlight this document where Precision Life outline their plans regarding clinical trials and next steps. It seems extremely optimistic and obviously they are a business, but it's the clearest explanation of what they plan that I've found. The stuff about protective biology is...

Perhaps I misread it. It was the juxtaposition of the psuedoscience comment and the tweet below. This is the more important question, I think. Would be interested if anyone knows the answer.

Just to highlight this article comes within a hair of calling long covid pseudoscience when it criticises Putrino. Also, do we see any of these markers the article author names that would need to be present to actually show T Cell exhaustion in the recent Hansen paper? Or in the intramural study?