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    Keystone symposium Long COVID and Other Post-Acute Infection Syndromes August 10-13 2025

    I wonder where they are getting their advice from? Surely not a certain jolly prof who's chummy with this Labour faction? Whoever it's coming from they are harming kids to an almost unthinkable degree. All because it's politically convient to forget covid. Never forget the widely publicised...
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    No “easy home runs”: Early Long COVID trials of Paxlovid and monoclonal antibodies failed, but the treatments still have potential Sick Times (AER002)

    I'm hoping the inclusion of 9000 LC patients in SequenceME will help the two spheres coalesce somewhat. Although thats a couple years off and not funded yet as far as we know.
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    No “easy home runs”: Early Long COVID trials of Paxlovid and monoclonal antibodies failed, but the treatments still have potential Sick Times (AER002)

    Agreed.
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    The impact of acute COVID-19 symptoms on insomnia: A longitudinal study among medical students, 2025, Zhu et al.

    Institutionalised exercise induced deterioration for long covid suffering med students. What a mad world we live in.
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    Genetics: OLFM4

    No worries, I believe so. I found these two links from a quick google. I think there is more info on S4ME but I am brain fogged right now! https://www.omf.ngo/pediatrics-me-cfs-deep-omics-profiling-and-longitudinal-study/ https://www.omf.ngo/omf-scientist-receives-grant-in-australia/ Edit...
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    Open UK BACME tube feeding survey 2025, closes 30th September 2025

    This is very needed but I trust BACME about as far as I can throw them.
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    Genetics: OLFM4

    This makes intuitive sense to me but that is probably meaningless. Two thoughts and you've probably already had both of them but just in case you havent: Chris Armstrong's team are/were doing a study that involved sampling people in active PEM with home visits iirc, so he might be a good...
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    Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Gardella+

    Type 1 interferons again!
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    [EV] proteomics uncovers energy metabolism, complement system, and [ER] stress response dysregulation postexercise in males with [ME/CFS], 2025,Glass+

    Does anyone know if Hanson's group are replicating this paper in a larger cohort? it seems really interesting and I would really like to know if it stands up. Especially after PRDX6, which is higher 15 mins after exercise here, popped up in DecodeME.
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    Genetics: PRDX6

    That's interesting. I don't know very much about the biology of exercise but I think I follow just about! Does anyone know if Hanson's group are replicating that paper in a larger cohort?
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    Genetics: OLFM4

    Very interesting! How would we test the hypothesis that type I interferons are involved in ME/CFS?
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    News from the USA, United States of America

    I feel like this paragraph definitely puts the dampener on things: Lots of people who have had covid have some kind of persistent markers of infection in their blood and no long covid samples. So it stands to reason these post exercise markers could be a similar phenomenon. Also they gave...
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    Genetics: PRDX6

    Downregulated in LC here: Strangely higher 15 mins after exercise in this small Hanson study:
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    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Well now I want to read his sci-fi novel!
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    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Exactly! I get really frustrated when people talk about this like it's a binary thing.
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    Criticisms of DecodeME in the media - and responses to the criticisms

    What an absolutely empty headed statement. Time for me to hit ignore thread before steam starts coming out of my ears! I wish he had the courage to say this to to the media when asked for comment instead of the usual weasel worded bollocks. But then they might be openly challenged on their...
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    BioVie Awarded up to $13.1 Million in Funding from U.S. Department of Defense to Evaluate Bezisterim (NE3107) for the Treatment of Long COVID

    That is worrying to me as a lot of people recover naturally in the first two years.
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    BioVie Awarded up to $13.1 Million in Funding from U.S. Department of Defense to Evaluate Bezisterim (NE3107) for the Treatment of Long COVID

    That's good to hear, will be good to get a prompt answer.
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    BioVie Awarded up to $13.1 Million in Funding from U.S. Department of Defense to Evaluate Bezisterim (NE3107) for the Treatment of Long COVID

    This is concerning. Does anyone know if they are tracking PEM as a secondary outcome like the Ely Baricitinib trial is?
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    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    That's an interesting thought. Conversely, there seems to be a lot of overlap between ME and Fibro. Maybe the people who have this chronic pain gene /have large amounts of pain with their ME symptoms - have fibro+ME.
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