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  1. V

    Genetics: FBXL4

    Have we seen this gene before in ME/CFS research? Or am I just thinking of the Crawley pediatric LC study?
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    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    Drat. Hopefully F&M can raise the funds some other way then.
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    Genetics: BTN2A2 and BTN3A3

    Understood. I certainly didn't think this gene was a definite slam dunk, just something that maybe strengthened the argument for JEs hypothesis. I hadn't realised that the IFNG/CD8 T CellI element was just from that one mouse model paper though. It would be interesting if we could come up with...
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    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    So, the 22 million kroner question is: do the DecodeME results strengthen the case for using Daratumumab?
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    Genetics: BTN2A2 and BTN3A3

    It has a certain appeal! It sounds like something from an old sci fi film. This does all look rather relevant to your hypothesis, unless I'm very much mistaken?
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    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Iirc they are actually planning a GWAS with Lipkins lab
  7. V

    Genetics: CCPG1

    Could you possibly expand on this a little? You've mentioned this idea before but I can't get my head around it.
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    Criticisms of DecodeME in the media - and responses to the criticisms

    :sick::emoji_rage: They seem to have a gameplan in place. I think it will be hard to counter until these findings are built upon sadly.
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    Donate to build on the work of DecodeME

    Does anyone have an opinion where the best place to donate currently is? Like through AfME or directly to Chris Ponting's lab? I understand the final pieces on finalising this study will be done by Chris and a small team on limited funding so maybe that is the best place to donate initally? Or...
  10. V

    Genetics: BTN2A2 and BTN3A3

    As we discussed in the preprint thread, the fact this is downregulated and it inhibits CD8 T cells and IFNG might be relevant to JE et al's hypothesis and related theorising.
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    Criticisms of DecodeME in the media - and responses to the criticisms

    Harriet Martineau, Alice James, Virginia Woolf at points...
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    USA: The RECOVER Initiative - Long Covid research

    Maybe i should reply on bluesky but LDN and Baricitinib are already being thoroughly trialed (although I guess LDN is being trialed in ME). GLP1 is an interesting idea I suppose, not sure what the rationale is. As for SGB, I am really skeptical, but I suppose it's better to have a trial than not...
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    Criticisms of DecodeME in the media - and responses to the criticisms

    Statistically, I think it's likely some of them are.
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    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Strep triggered me and my partner's illnesses too.
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    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Wow, that's really intriguing.
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    Closed UK: DecodeME updates, was recruitment thread.

    A massive thank you to the whole DecodeME team! I'm very grateful to everyone who made tonight possible. Lets hope its the start of an interesting and fruitful journey!
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    DecodeME in the media

    I really wish they would just give it an effing rest.
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    Criticisms of DecodeME in the media - and responses to the criticisms

    I really wish they would just give it an effing rest.
  19. V

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    So if the gene inhibits the proliferation of CD4+CD8 t cells activated by IFNG does that provide evidence for or againsts JE et als hypothesis? Inhibition would suggest against to me but I know little about these things.
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    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Looks like the top hit gene has never been mentioned on here before...
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