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I've had fodmap sensitivity for ages. I blew up one of those hydorgen breath tests and got a record score, suggesting my body wasn't coping well with them. But recently i've begun to suspect histamines. Keeping to the fodmap diet simply wasn't providing 100% effects. And even on keto I seemed to...

Fairly simple technique used. Pull out some PBMCs and run them through the Seahorse machine. Then create this BHI index based on the numbers it spits out. The findings appear significant between groups and also to distinguish severity levels. I wonder if it would be even more sensitive with...

I recently ran a self-experiment, reducing my beta-blocker dose for several weeks before reinstating it. The effect was noticeable within days. More beta-blocker: more capacity. I'm mild and have quite bad POTS and I strongly believe in a role for beta-receptors in my symptoms. I'm also on an...

It's an antibody, available to researchers. Quite expensive at $1486 for a milligram: https://www.antibodysystem.com/product/8926.html Perhaps one day everyone over 50 will be taking it each morning alongside their fish oil and celebrex and statins!

In the most excitable parts of the longevity research community they talk about "escape velocity". You live long enough to be there once the anti-ageing drugs begin accumulating fast enough that you don't die! It's not realistic, but there's a germ of truth to it, and you can see it in the...

I should add that not only are the benefits visible in mice engineered to be low in IL-11 but also in mice given anti-IL-11 therapy once they were already old.

Results here are pretty striking. Will be interesting to see how it pans out in humans if they try it for fibrotic lung disease. However the thing about ageing research in people is it takes a long time to collect data! Still I'm very excited about ageing research because it seems to...

2024 Jul 17. doi: 10.1038/s41586-024-07701-9. Online ahead of print. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan Anissa A Widjaja # 1 , Wei-Wen Lim # 2 3 , Sivakumar Viswanathan 2 , Sonia Chothani 2 , Ben Corden 3 4 , Cibi Mary Dasan 2 , Joyce Wei Ting...

Surprised that the very first iteration of the virus caused more long covid than the delta-era one, which if i recall correctly, caused more severe acute illness. But overall this matches my prior which is that as the virus mutates to cause less serious illness, there's a lower rate of long...

The alternative to publishing an n=1 study isn't usually an n=10 study, it's putting it in the file drawer so nobody ever hears about it. I welcome all data of all kinds and all sample sizes. Nobody sets out to do half-finished, under-populated, under-powered studies but logistics can get in...

For someone like me, my earning power is very much linked to how well I feel. I have very short-term projects that I can complete on a day I feel well. If I'm in a good period I can make good money. At other times weeks go by with no earnings.So my health shows up in my bank account. But that...

Simple but massive breakthrough to have a measurable correlate of OI. If you can measure it you can manage it.

So, this was an attempt to replicate two-day cpet with a really big sample and the differences persisted but don't look very big. Is that a fair summary? Is that why most of this thread is discussion of the inclusion criteria? People trying to explain why the differences don't look big? I...

So you think there's sufficient empirical evidence to disprove the concept of viral latency / viral reservoirs in tissue? What about John Chia's work?

I enjoyed the thread. There's definitely an emerging consensus among certain scientists in the US that there is a persistent pathogen (or pathogens). Do I think that's 100% likely to be true? No, the hit-and-run hypothesis is still plausible. Do I think it's a good clue worth digging into? 100%...

she is certainly keen to distinguish them. Especialy to the exteent that long covid cohorts include people who were hospitalised and have organ damage; and that me/cfs is not caused by coronaviruses (and maybe, just maybe, all prior mecfs is from one virus.) and that mecfs patients have been...

This is a highly ambitious paper. Big sample and some very sophisticated statistical analysis. I like it. This study is worth combining with all our other metabolomic studies to see what is consistent and what is not. It seems to find a role for gut microbes, and their products, espeically...

This thesis seems to be part of the evidence base for Hanson's swing to believing there's persistent infection. I observed a population of T cells that were positive for both CD4 and CD8 markers in both cohorts, as well as differences in the proportion of Tox+ cells within this population...

For those of us who haven't heard of neutrophil extracellular traps before: The Expanding Role of Extracellular Traps in Inflammation and Autoimmunity: The New Players in Casting Dark Webs Stephanie U-Shane Huang and Kim Maree O’Sullivan* James L. Stafford, Academic Editor Author information...

I just googled thesis embargos. They seem to imply something might be seeking publication or patenting. Which may be a hopeful sign.