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authors: Stanford Journal: PNAS. cases: 650 controls:661. p-values: some very low indeed. tl;dr this study is more likely than most to have found something that is true. That is exciting since what they have found looks relevant and novel.

This idea of heteroplasmy could also be relevant to mecfs: you need have the genetic problem in only some of your mitochondria for symptoms to develop. It would be an obvious way to distinguish mild moderate and severe.

Whenever I read about people having problems with the various complexes in the mitochondrial chain I think about Hwang and WASF3. He found in his patient that WASF3 inhibited two complexes joining together to make a supercomplex, which would run more efficiently (and then detected high wasf3 in...

Got excited by the title, but this is a single author hypothesis paper. To stand up the hypothesis will require a bunch of funding.

Doesn't look like too much to me? They checked 94 million genetic variants in patients, found 398 differnt mitochondrial ones in patients, there was one pathway that had variants in five/13 patients, being the Mucin von willebrand pathway.

There's lots of known unknowns in this space like plasma vs serum; pbmcs vs skeletal muscle; sample storage; collecting samples at different times of day, after different amounts of exertion, etc. There's also biological sex and disease duration which muddle things up. And severity. All of...

I emailed Walder and he said : "No drugs yet from the me/cfs study, should be finding some later this year if all goes well". He understands as well as we do that when a drug emerges from this process it is merely a candidate; the process increases the probability that this compound may help...

Look, I also don't think this is the research process most likely to lead to a cure. I do find myself attracted to a philosophical approach that seeks glimmers of light, even amid human and institutional frailty.

There's a small blurb here about the work Deakin are doing on me/cfs: https://med-projects.deakin.edu.au/projects-2023.php yes, they write me/csf some of the time! Like many new studies it's being done by people who've wandered into this field from elsewhere; that lack of deep background...

I don't want to become the defender or spokesperson for this technique, but it does proceed based on that premise: we dont know what's wrong, so take an unbiased approach to see what drug makes things look like healthy cells again. Walder used it in diabetes, he told me. Here's a couple of his...

This could also be a good thread to share a post I found in a facebook group for the in-ear wearable device that measures bloodflow to the head. I'm sharing this post because I think it moves the goalposts in a really useful way; if everything else is just a proxy for getting blood to the head...

I've recently been focussing more on the orthostatic intolerance side of my symptoms; i regret not looking into this more before because there's some simple things that seem to help. I have bought compression garments, which I'd used before and kind of given up on but these new ones seem to...

@Creekside I suppose if the book made all the claims you're guessing it makes it would be a bad book! I asked chatGPT though and it said guessing at what's inside a book is not in the top few ways to find out what's in a book. ;)

I just joined their facebook group where they are sharing some data from some staff members with POTS. (Seems like they hire people with POTS mostly, must be a weird office!) I also watched this video there's an interesting moment where the researcher shows how drinking coffee causes her...

There's the consumer version which prioritises battery life(right in pic) and the test-bed one that runs continuously and produced the charts above (left in the pictire below. It is bigger) They're also trying to program the consumer one so it starts measuring more intensively when a person...

It's expensive; not totally out of reach if it actually delivers better ability to manage symptoms. For me i'd need to buy an iPhone to make it work so that's extra expense too! However it's not available in Australia so it's all a bit academic.

I just watched this video and found it quite intriguing. The following four screenshots show examples of the device measuring drops in blood flow. It measures a proxy for blood flow to the brain but nevertheless looks useful @SNT Gatchaman you called for this to be done and they have...

One thing Levin won't stop talking about is the idea that electric charges predate neurons by a long way and are a more ancient way of coordinating and arranging things. They're present in algae, for example. I'm with him up to that point but he proceeds to talk about electricity as a form of...

This is why the book review starts on the defensive ! People are strongly repelled by the idea of electricity in biology. Among the ways they do it: https://en.wikipedia.org/wiki/Gap_junction Among the cool things explained by electric charge is how embryos work out left from right, placing...

Here's a graphic that shows Hwang's new wasf3-centric view of the universe! Figure 1. A model of how WASF3 may play a central role in regulating metabolism and immunity in response to ER stress and other signals. Upon ER stress, the level of WASF3 protein may rise at the contact sites...