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Online treatment regimens in chronic fatigue syndrome From the book, The Scientific Basis of Fatigue Jaime Navarrete, Juan P. Sanabria-Mazo, Randy Neblett, Juan V. Luciano [Line breaks added] Abstract Some psychological therapy approaches have been empirically supported for the improvement of...

The risk may or may not be the same. But the benefit is exponentially higher. If a patient takes it themselves, it might help that one patient and maybe a couple more that are convinced by an anecdote. If a patient takes it as part of a trial, it could help millions of patients get that...

See thread: International Declaration in Support of Research and Drug Development for ME/CFS and Long COVID

This was presented at the International ME/CFS Conference 2025 a few months ago: Link "Prof Christian Puta provided a poster presentation on behalf of Prof Philipp Reuken on differentiating ME/CFS through Raman spectroscopic profiling of immune cells. In their study, Raman spectroscopy was...

Differentiating ME/CFS Through Raman Spectroscopic Profiling of Immune Cells Anuradha Ramoji, Frida Naumann, Tze Ching Yeo, Sabine Vonderlind, Aikaterini Pistiki, Hulya Yilmaz, Iwan W. Schie, Oleg Ryabchkov, Thomas Bocklitz, Andreas Stallmach, Jürgen Popp, Philipp Reuken [Line breaks added]...

I'm happy to see that they'll be measuring IGHV3-30 during this study. We'll see if there's more confirmation that it's high, and maybe see how it relates to improvement, if there is any.

Bluesky thread from the author going over the results. A couple interesting points:

Thanks. It looks like the protocol, not results, though.

See the following relevant thread: Sweden: Have the ME and CFS clinic in Gothenburg found a loophole to avoid the diagnosis ME?

From the first citation: Quite a stark difference. Some discussion here: https://www.s4me.info/threads/coq10-coenzyme-q10.13640/post-259964

Up to now, I've mostly tried to avoid reading or posting research that involves animals, because I find the practice often is abhorrent, and I don't want to support more of it happening. Making mice fear for their life in a swimming test, injecting animals with chemicals that we would never...

Exploratory Study on Autoantibodies to Arginine-rich Human Peptides Mimicking Epstein-Barr Virus in Women with Post-COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Friederike Hoheisel, Kathrin Maria Fleischer, Kerstin Rubarth, Nuno Sepúlveda, Sandra Maria Bauer, Frank Konietschke...

Crosslinking this announcement from the ME Association thread: https://meassociation.org.uk/2025/08/the-me-association-awards-decode-me-the-howes-goudsmit-award-2025/

NEGR1 and DCC were the only two genes that were significant in both males and females (using different tests). NEGR1 and DCC also happen to be the genes closest to the 10th and 15th most significant loci in the DecodeME study (though below the genome-wide significance threshold at 1.19e-7 and...

Sex-stratified genome-wide association meta-analysis of major depressive disorder Jodi T. Thomas, Jackson G. Thorp, Floris Huider, Poppy Z. Grimes, Rujia Wang, Pierre Youssef, Jonathan R. I. Coleman, Enda M. Byrne, Mark Adams, BIONIC consortium, The GLAD Study, Sarah E. Medland, Ian B. Hickie...

Stellate Ganglion Block for the Management of Long COVID Symptoms: A Retrospective Cohort Study Michael C. Chiang • Kathryn M. Satko • Christina Shin • Beau P. Sperry • Meghan L. Cabral • Zack Crockett • Richard Gao • Robert J. Yong • Samuel P. Ang • Stacey L. Burns • Alexander J. Kim [Line...

Impressive investigation! It looks they want to appear to be working within Canadian criteria guidance, but if they are really not diagnosing anyone with ME/CFS, they're almost certainly not following the "spirit", or original intent, of the criteria.

On the other hand, we're talking about a disease where proteomics and exercise tests have already been tried several times in less severe people. If there actually are differentially expressed proteins, we expect them to probably have tiny effect sizes, and when you're correcting for a hundred...

The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers Lei Wang, Yujia Xu, Xiang Zhong, Guiping Wang, Zijun Shi, Can Mei, Linwanyue Chen, Jianbo Zhan, Jing Cheng [Line breaks added] Abstract Chronic fatigue syndrome (CFS) is a...