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This article has been retracted, see post #31. ---------------------------------------------------------- Causal Relationship Between Diet, Lipids, Immune Cells, and Chronic Fatigue Syndrome: A Two-Mediation Mendelian Randomization Study Jixu Li, Qi Qin, Yiran Zhu, Yulu Qian, Jialu Yin, Xin...

Really? She couldn't figure out whether or not Hilda was talking about the definition of ME/CFS changing? It might have made sense to look at the IOM report that Hilda cited, the subtitle of which is "Redefining an Illness". If the review is about "chronic fatigue" in general, she doesn't...

Again missed the point. She's saying the Cochraine review is out of date because newer studies have more evidence on harms, not that the review didn't adequately assess harms in the studies it looked at.

- https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003200.pub9/detailed-comment/en?messageId=457323262

They seem to have not understood her point. They are the ones that mentioned NICE in their paper, and she's pointing out that they mentioned the old one that agrees with their conclusions instead of the new one that does not.

Collecting all the threads we have about daratumumab: ME/CFS Patent: Method for the treatment of CFS using an inhibitory or cytotoxic agent against plasma cells, 2021, Fluge, Mella [Protocol] 2022 Pilot study in Norway - Daratumumab in ME/CFS [Protocol] Norway: Study of Daratumumab Injections...

Similarly: NK Cell Phenotype Is Associated With Response and Resistance to Daratumumab in Relapsed/Refractory Multiple Myeloma (2023, HemaSphere)

Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD Yuanxin Zhong, Larry W. Baum, Justin D. Tubbs, Rui Ye, Lu Hua Chen, Tian Wu, Se-Fong Hung, Chun-Pan Tang, Ting-Pong Ho, Robert Moyzis, James Swanson, Chi-Chiu Lee, Pak C. Sham & Patrick W. L...

Characterising Postural Orthostatic Tachycardia Syndrome (POTS) triggered by a viral illness compared to concussion or trauma Gemma Wilson, Marie-Claire Seeley, Pauline Slater, Dennis H. Lau, Celine Gallagher [Letter to the editor] Link (Clinical Autonomic Research) [Paywall] No abstract...

[68Ga]FAPI PET/CT reveals increased pulmonary fibroblast activation protein expression in long COVID patients after ICU discharge B. van Leer, M. Londema, Ö. Kasalak, J. H. van Snick, M. L. Duiverman, J. C. Kuijvenhoven, M. D. de Kruif, D. E. Oprea-Lager, K. Pabst, M. E. Hellemons, H. H...

Nice find. From daratumumab for ME/CFS: Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al Plot of baseline NK count vs improvement from video posted here.

Is it placebo effect or people just naturally improving early in the illness?

I made a thread here: Genetics of PANS/PANDAS, 2025, Lachman et al

Genetics of PANS/PANDAS Herbert M. Lachman, Jennifer Frankovich, Peter J. van der Spek, Janet L. Cunningham [Line breaks added] Introduction Pediatric Acute-Onset Neuropsychiatry Syndrome (PANS) is an enigmatic condition characterized by the abrupt onset of obsessive-compulsive disorder (OCD)...

@Jaybee00 let me know about this: ---- - https://xcancel.com/mildTin/status/1936644648078074275 Discussion of trial starts at 36:25

RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Drug: Ibudilast 10mg pills, 2 pills twice per day Other Names: Drug: Pentoxifylline 400mg pill 3 times per day Other: Placebo Placebo matching ibudilast, 2 pills twice per day OR placebo matching...

I searched for any results on S4ME for the genes associated with SNPs above. Here are the ones with matches: PDE4B Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+ Evidence of shared genetic factors...

Just copying their findings from the supplementary tables so the genes come up in forum searches. For the snps, I converted them to the genes they map to with dbSNP's API. Variants Transcription Proteins

Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study Eleni Friligkou, Solveig Løkhammer, Brenda Cabrera-Mendoza, Jie Shen, Jun He, Giovanni Deiana, Mihaela Diana Zanoaga, Zeynep Asgel, Abigail Pilcher, Luciana Di Lascio...