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I wish they would have tested more nights. REM looks to have mostly recovered by night 7, so far all we know, it was only really low on a single night immediately after running. Total sleep time does seem to still be a little low at night 7 (6.7 hrs) compared to night 21 (8.0 hrs).

I calculated the actual time in each stage using the percentages from Table 2. Minutes of slow wave sleep was modestly higher (11.8%) at night 1 compared to night 7. But minutes of REM was much lower (-63.7%) on night 1 compared to night 7. It looks like the main effect of the marathons was...

That would be my first guess on seeing that data. This similar statement from the text suggests they don't necessarily think REM decreased because it isn't necessary, but that slow wave sleep increased because it is important in recovery: Edit: But the fact that total sleep time decreased...

It seems like they're just inferring that based on the person having less REM after these marathons. Some more from the paper about intense exercise's effect on sleep:

Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart Brief Summary This placebo-controlled, randomized, blinded, two-arm phase II study will test the safety and potential efficacy of the targeted mAb, Sipavibart (formerly...

Impact of extreme physical exercise (28 consecutive marathons) on sleep time and structure, 2025, Buela-Casal et al In this study on a single runner, sleep quality (time asleep, sleep latency, etc) was much worse immediately after running 28 daily marathons and slowly returned to normal over...

Maybe 28 consecutive marathons (!) is what it takes for a healthy person to experience PEM.

Impact of extreme physical exercise (28 consecutive marathons) on sleep time and structure Gualberto Buela-Casal, Noelia Ruiz-Herrera, Alejandro Guillén-Riquelme, Carlos Zamarrón, Francisco Gude-Sampedro Objective It is known that physical exercise influences sleep, however, the effect in...

Affective disorders and chronic inflammatory conditions: Analysis of 1.5 million participants in Our Future Health Arish Mudra Rakshasa-Loots, Duncan Swiffen, Christina Steyn, Katie F. M. Marwick, Daniel J. Smith [Line breaks added] Abstract Chronic inflammation is associated with psychiatric...

Video on the ME/CFS Research Foundation Youtube channel. It's a really catchy song. The title translates to "What we want". And here is a Claude translation of the auto-generated lyrics: Google translation of the description:

Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection Thor Ueland, Rebecca Jane Cox, Annika E. Michelsen, Elisabeth Berg Fjelltveit, Kari Otterdal, Tuva Dahl, Fan Zhou, Rebecca Elyanow, Pål Aukrust...

Impressive looking results. Only 1 dropout out of 31 in the agomelatine group. I wonder if it'd be better to individually assign participants to placebo or active, instead of assigning them to "group A" or "group B", because for the group method, if a clinician is able to guess a single...

Agreed, that sounds like a much better world.

I don't understand this part. The risk is that a drug doesn't work and makes no money. They can't choose to not bear the cost of making no profit.

I think the main question is if the really expensive drugs will still get made. Pharma companies have to spend billions, not only on the drugs that eventually make a profit, but on plenty that never make a dime. If they have to sell these billion dollar drugs at market prices that might not...

I'm working with a beginner's understanding, but I thought we've got memory B cells and long-lived plasma B cells for any particular antigen, and the memory B cells continually create new long-lived cells to replace those that die. So if Dara wiped out the long-lived cells, after some time, the...

FYI, in case anyone didn't notice at first (like me), the paper is from 2014.

PEM definitely affects my diet. I eat more total calories, and eat less variety because I have less energy to prepare foods. Hopefully, my basic understanding of granger causality is correct, where it would essentially "control" for previous upright time, so it should mitigate confounding from...

I'm still working on my nutrient tracking experiment. Just wanted to outline the direction I'm hoping for it to go. Data collection consists of two parts: Nutrients Using the app Cronometer, I am tracking the weight of every food I eat. Except for very rare exceptions, I only eat foods that...

I guess because the final equation is based on positive differences minus negative differences, so zero differences wouldn't have a place. But in terms of the theory, my brain is too foggy to follow this right now, but these two webpages give some context...