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I was looking at that, wondering if BMI was the reason for the increase (matched for sex), but they seem pretty closely matched for BMI as well: HC: 24.0±2.6 ME/CFS: 24.4±4.2 Maybe the larger variance in BMI in the ME/CFS group could affect things? Edit: Oh, not perfectly matched for sex like...

Now published. In terms of the abstract, other than minor spelling and formatting changes, the only change was removing the mention of IL-8. ---- Background Several studies reported long-term consequences of severe COVID-19. However, pathophysiological mechanisms of Post-Acute Sequelae...

Exploring Genetic Susceptibility to Internalizing Symptoms within the DSM: Network Analysis Selka Sadiković, Ljiljana Mihić, Radomir Belopavlović, Bojana M. Dinić, Nada Tokodi, Nataša Vučinić, Mechthild Prinz, Zoran Budimlija & Snežana Smederevac [Line breaks added] Abstract This study...

54 ME/CFS and 27 HC. 6494 proteins tested. 751 with significant q values. Down: intracellular proteins, including histones, metabolic enzymes | Up: immune system, metabolism | Up or down: vascular function Controlling for metabotype (what is metabotype?) and SF-36 physical function score...

That's interesting. Hydrocortisone cured her fear of gaining weight? I feel like anorexia is one of the best examples of a condition your doctor would send you to a therapist to fix, yet a cheap medication did the job.

Just added.

I also just realized that CD24 doesn't have the lowest p-value. I misread the chart previously. It does have the largest odds ratio of the 28 traits, but a couple others have lower p-values.

The authors confirmed that all traits reported in the paper were based on unadjusted p-values. While FDR values were calculated, the only place they were reported was in the supplementary table. They weren't used for identifying traits of interest, and the authors acknowledged that the wording...

Here's the trial registration: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=OTgyNzA=

There's a long criticism on PubPeer of this protocol that in large part echoes the points made here. The summary at the end:

The registration for Nancy Klimas's CoQ10 phase III trial for gulf war illness shows that the study was completed in 2020, and they subsequently added the results to that page. The differences mostly seem modest and aren't consistent across outcomes (e.g. SF-36 - more improvement in CoQ10...

I think that basically covers it. With the added component, which is vital to MR, of excluding SNPs that can directly cause the disease itself [edit: through a pathway other than through the] intermediate trait, so that one can infer causality of the intermediate trait (immune cell trait in this...

From the GWAS they reference: So for example, for the trait "CD24 on CD24+CD27+", the original GWAS detected the SNPs associated with expression of CD24 on these cells. In theory this thread's study then checks if any of the immune cell-associated SNPs from that other study are associated with...

They tested 731 phenotypes and reported that 28 were significant and passed their sensitivity analyses. That's 3.83%. Pretty close to the 5% you'd expect to be under p of .05 by random chance. I suspect that a large portion of these are false positives.

So it sounds more like long COVID caused vaccination rather than vaccination caused long COVID.

Now published: Link | PDF

Hypothalamic-pituitary-adrenal Axis in Patients Presenting to Psychosomatic Medicine with Fatigue Sunao Matsubayashi, Makoto Yamashita, Takeshi Hara, Makito Tanabe, Shuichi Matsumoto Abstract Many patients with fatigue are referred to psychosomatic medicine, but few studies have examined the...

Serum antineuronal antibodies in patients with post-COVID-19 condition − association to intensive care Tatiana Posharina, Mikko Varonen, Hanna Jarva, Mari Kanerva, Helena Liira, Sini M Laakso [Line breaks added] Highlights • Antineuronal antibodies found in 12.1% of post-COVID-19 patients...

I'm looking at Supplementary Table 1 where there is a column called pval which matches the p values reported in the paper. They used almost all of the immune cell exposures that were under p<.05 (28/31). There's a p_fdr column where one row is .83 and the rest are over .98. So I'm not really...

Quite a lot of associations. Maybe someone can weave a story out of it. 21. Armstrong CW, Mensah FFK, Leandro MJ, Reddy V, Gooley PR, Berkovitz S, Cambridge G. In vitro B cell experiments explore the role of CD24, CD38, and energy metabolism in ME/CFS. Front Immunol. 2023;14:1178882. Article...