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It's hard for me to read likely in that way. Wouldn't 'potentially', 'might', or 'may' make sense like these other bits that seem to be said in the same context? 'Some of these antibodies might fulfil a ‘broadly neutralising’ role' The suggestion is that FcγRI may fulfil (amongst other things)...

I'm not sure if it was the intention, but this comes across as confident that IFNG is related to symptoms. Extraneous parenthesis at the start.

It's now pretty clear that this was going on for me for years before I developed full blown disabling ME/CFS. I look back at a vacation I took about 6 years prior to onset, where I was excited and feeling great at the beginning and just kept decreasing in function over a couple weeks. I kept...

Maybe this could be another reference, though hard to know if the association is more with duration or severity. Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome (Sato et al, 2021)

For completeness, I'll add that the Swedish Dr. Gottfries in Sweden said he had an influx of patients in the 1950s during the "asian flu" H2N2 pandemic. https://s4me.info/threads/immune-stimulation-by-vaccination-e-g-staphylococcus-toxoid-vaccine-bcg.41358/#post-568807 Though I'm not sure he...

One thing I didn't mention in the above post, out of an abundance of statistical caution: When I first ran the GSEA on the Genebass dataset with the 52 clusters that were returned by STRING for the HEAL2 genes, I noticed that only 33 gene sets were tested in the analysis. I remembered that the...

Well they're basically models trained in different ways, pulling out different genes. If they included some other third random ML model that also didn't do better than chance, that wouldn't make me more confident about the one that did. Isn't it possible that by chance one model returned genes...

I guess I'm not aware of the prior knowledge about these. HLA-C, there was the one HLA fine mapping study. But what was the evidence for synapses before this?

Is there a consensus? One thing for me: to lose virtually no accuracy on the test set (AUROC 0.677 to 0.670) makes me think there was a fair bit of randomness playing a part due to the size of the independent set, and it just happened to be high accuracy with this small group by chance. How...

https://www.crd.york.ac.uk/PROSPERO/view/CRD42024573955 If I'm reading the registration correctly, they did the searches in August 2024. Does anyone know a good reason you wouldn't include all studies up to the most recent available?

A lot of double negatives, but I think in general they're referring to actual decreases.

Graphic design student designing a campaign. Just skimmed the thesis, but here are some of the visuals:

Concept Campaign: Raising Awareness of ME/CFS Among Unaffected Audiences Iga Domińczuk LAB University of Applied Sciences Institute of Design and Fine Arts Bachelor of Culture and Arts, Packaging and Brand Design Abstract Visual communication has the power to challenge stigmas and public...

Effectiveness of Exercise-Based Rehabilitation in Chronic Fatigue Syndrome: A Systematic Review and Meta-analysis Antonio De Vera Martín, Alberto Díaz Salazar, Isidro Miguel Martín Pérez, Sebastián Eustaquio Martín Pérez [Line breaks added] Abstract Chronic Fatigue Syndrome is a complex and...

Ah now I understand! I replaced those acronyms in my post now.

Unfortunately, I don't think I could do a good job explaining it as I don't fully understand the paper. But a few bits: CBF is cerebral blood flow, or how much blood is flowing into the brain per minute. CO is cardiac output, or how much blood the heart pumps per minute. They did a tilt test...

Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation and Leukocyte Telomere Length: 4-Year Findings from the VITAL Randomized Controlled Trial Haidong Zhu, JoAnn E. Manson, Nancy R. Cook, Bayu B. Bekele, Li Chen, Kevin J. Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee, Yanbin...

I did my plan of running GSEA on the HEAL2 genes using protein clusters provided by STRING as gene sets, then using the most significant of these clusters to run a second GSEA on the Genebass data for ME/CFS in the BioBank. Nothing came out very significant, the lowest was FDR = 0.220, but maybe...

[...] Herpesviruses and a Faulty Antiviral Response may Contribute to Chronic Multi-Symptom and Multi-System Illnesses in U.S. Military Veterans Brandon Cox, Paula Goolkasian, Irene Mena Palomo, Marshall V. Williams, Sean R. Maloney, Maria Eugenia Ariza [Line breaks added] ABSTRACT Chronic...

Comparison of long COVID, recovered COVID, and non-COVID Post-Acute Infection Syndromes over three years Caleb R. Carr, Nicole L. Gentile, Jeanne Bertolli, Warren Szewczyk, Jin-Mann S. Lin, Elizabeth R. Unger, Quan M. Vu, Nona Sotoodehnia, Annette L. Fitzpatrick [Line breaks added] Background...