I think we can probably forget about the sperm. I took a random sample of 14 genes from the 17,000 genes in the Zhang file, and about the same proportion are high in sperm-related cells:
Edit: 14 more, only 1 definite came up by random this time:
Going to do 28 more.
Edit 2: One had no...
That's a really cool resource, thanks. For reference here is the paper the genes are from: Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis (Das et al, 2022, J Transl Med)
And here are the 14 genes they found, linked to their Protein Atlas cell type page (GC links to...
The first paragraph you're talking about is the discovery cohort, on which the model was trained. It's made up of the Stanford and CureME cohorts. After training the model, it's tested on the independent dataset, the second paragraph, which is made up of different people, the Cornell cohort. The...
On the independent ME/CFS dataset, though, there is more of a difference (first quote is the simulated independent dataset, +0.358 improvement over HEAL, second quote is the ME/CFS independent dataset +0.124):
I was wondering why they wouldn't do this, and instead used some kind of simulated dataset, but then I thought maybe it's because the STRING database basically has all the "answers" for well-characterized diseases. So maybe if the model is looking at a well-studied disease, and sees high...
I think it was Janeway's Immunobiology I remember it from, though I don't have access to it now, that said
type 1 response is mainly ILC1, Th1, and IgG for intracellular pathogens,
type 2 is ILC2, Th2, and IgE for parasites/intestinal bacteria,
and type 3 is ILC3, Th17, and maybe IgA for...
Thanks! This kind of activity is one of my favorite things to do. I wish I could spend hours per day learning about this kind of statistics related work, but I'm energy limited to around 10 minutes per day on average, with occasional overreaches like this when I get excited about an idea.
Yes...
The preprint says all the genetic data is on Synapse.org (have to request access, not sure how easy that is), so maybe someone who knows how can test that.
Edit: The note about the data was added in version 2 of the preprint.
Estimating Long COVID-19 prevalence across definitions and forms of sample selection
Pietro Giorgio Lovaglio, Fabio Borgonovo, Alessandro Manzo Margiotta, Mohamed Mowafy, Marta Colaneri, Alessandra Bandera, Andrea Gori, Amedeo Ferdinando Capetti
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Abstract
Long COVID (LC) is...
Long COVID-related blood-brain barrier breakdown and microstructure in older adults are modified by sex and Alzheimer’s disease genetic risk
Emilie T. Reas, Austin Alderson-Myers, Seraphina K. Solders, Qian Shen, Charlotte S. Rivera, Xin Wang, Jordan Stiver, Sarah J. Banks, Jennifer S. Graves...
I think in the US, anyone with private or government health insurance can get it for free. Both doctors I've had over the years have asked if I want a flu and COVID shot when the time of year comes around.
This study?
Exercise does not cause post-exertional malaise Gulf War Illness: A randomized, controlled, dose–response, crossover study, 2024, Boruch et al.
I would hope that didn't cause a decrease in discussion. The thread was almost all criticism.
They possibly showed that not everyone with...
Incidence of Long COVID diagnoses in 3.6 million US Medicare beneficiaries with COVID-19
Yasin Abul, Daniel A Harris, Preeti Chachlani, Kaleen N Hayes, Andrew R Zullo, Vincent Mor, Stefan Gravenstein
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Background
Long COVID incidence and risk factors in older adults need to...
Long COVID and endometriosis: a systematic review and meta-analysis
Alexandre Vallée, Maxence Arutkin, Pierre-François Ceccaldi, Anis Feki & Jean-Marc Ayoubi
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Abstract
Long COVID conditions entail the persistence of COVID-19-related symptoms for at least eight weeks...
Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program
Gita A Pathak, Dora Koller, Brenda Cabrera-Mendoza, Alice B S Nono Djotsa, Frank R Wendt, Antonella De Lillo, Eleni Friligkou, Jun He, Manuela R Kouakou, Linh M Duong, Jacqueline Vahey...
I think a few studies that found increased COVID proteins in LC. It's been a while since I read it, but I think this opinion paper covers the main ones...
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