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It's just assumed that participants in an unblinded trial filling out a questionnaire differently means their symptoms improved. No mention of the possibility of bias related to subjective outcomes in the limitations.

It looks like you can download summary stats on the GWAS Atlas website. I'm not sure if it has data from exactly the same study you linked, but it has several for depression. For example, there's a depression trait which looks like it has NEGR1 as significant. Clicking the link next to "File"...

Multiple Sclerosis Rheumatoid Arthritis

Some posts about a previously planned GWAS in the USA were moved to: USA: Center for Solutions for ME/CFS - news and updates from Columbia University's NIH funded center, Lipkin

From the first study: Ultra-rare variant in CACNA1B found in two siblings with PANS, and the same variant was previously found in a woman with ME/CFS+anorexia. Edit: And I don't know how related CACNA1B and CACNA1E are, but the latter was the closest gene to the 23rd most significant locus...

I don't think I've seen all the discussions, but I've seen you refer to psychiatric disorders as disorders of "thought" or something along those lines. Relating to "thoughts" and "mind" is barely a concrete category in my opinion. Anxiety to me feels like the mental version of physical pain -...

"Psychiatric" feels to me like an almost useless term. The difference between obsessing about a specific thought (OCD), having little motivation (some forms of depression), yoyoing between high and low mood (bipolar disorder), and seeing things that are not there (schizophrenia) seem about as...

Some discussion has been moved to the following thread: Heathrow incident 8/9/25 claimed to be mass psychogenic illness

Acute Effects of Osteopathic Treatment in Long COVID-19 Patients with Fatigue Symptoms: A Randomized, Controlled Trial Ulrich M. Zissler, Tino Poehlmann, Rainer Gloeckl, Sami Ibrahim, Kerstin Klupsch, Tessa Schneeberger, Inga Jarosch, Andreas Rembert Koczulla [Line breaks added] Background...

Prevalence, Severity, Concomitant Factors, and Natural Trajectory of Insomnia in Patients with Long COVID Jamie Hansel Robinson, Halle Bakir, Alicia Shanti James, Marquita S. Brooks, Stephen J. Thomas, Kristine L. Lokken Background/Objective Insomnia is a clinically important symptom in Long...

Much more rare than ME/CFS apparently (and opposite sex bias): I saw a few papers that were case reports of sudden onset OCD following COVID. Maybe COVID-related PANS is too rare for anything other assorted case reports. SARS-CoV-2 related paediatric acute-onset neuropsychiatric syndrome...

PANS has to be related to ME/CFS and long COVID, right? Sudden onset of a brain-related condition shortly after any of a number of different infections? The AI summary says it can occur after COVID infection. If so, I'm surprised I haven't really seen it mentioned in any long COVID papers as...

Effect of low dose naltrexone for long covid: a systematic review Oyungerel Byambasuren, Tiffany J Atkins, Shaira Baptista, Paul Glasziou, Samantha Chakraborty [Line breaks added] Background Long covid is a debilitating chronic condition, and the effect of low dose naltrexone (LDN) on its...

Is the idea that symptom improvement would require antibodies to be stuck to CD38, or that just one of these events is enough to interrupt a positive feedback loop for improvement even after antibodies are gone? Is the former (antibodies stay stuck) possible with the length of time (> year) that...

Oh, I didn't see before that the cyclo trial only looked at those two specific alleles that were significant in the Lande study. That explains why it's the exact same alleles.

Hormonal Fluctuations and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Women: The Role of Menstrual Cycle and Menopause Mehak Khan, Sidra Anees, Muhammad Muthar Anees, Komal Khalid Chaudhry, Syeda Marium Rashid Zaidi, Vishan Das, Rimal Rashid [Line breaks added] Abstract Myalgic...

- https://en.wikipedia.org/wiki/Autoimmune_hemolytic_anemia There's an autoimmune disease for hemoglobin carrying cells, but I think anemia would be expected, which I don't think we have evidence for in ME/CFS.

Yep, at least. I wonder if there's a smaller number than 24M where they would still do the whole trial, just with fewer participants. Maybe they've already reached that smaller number since they're talking about starting treatment in September.

Here's what they said they were at on August 26 (about two weeks ago): https://www.me-foreningen.no/me-fondet-over-1-million-og-er-pa-na-facebook/ (Text from auto-translated version)

Thanks. Am I understanding right then that even if covid specific plasma cells were injected into the brain but not actually specific to anything there, you'd still see the bands show up from their antibodies?