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Sure, I don't know how large of a CI would be expected if they had only run it once. I was just worried that it would actually be much bigger and cross 0.5, and that the genes may just be more or less random, and they happened to get 0.670 by chance on the test set. I'm thinking more about this...

Thanks @jnmaciuch. So maybe not quite as exciting as what I thought was happening which did seem too good to be true: lots and lots of synaptic genes coming up independently. As far as I understand your description, it's something more like, if the model sees some variants in, say, both NLGN1...

Using Single-Cell Raman Microspectroscopy to Profile Human Peripheral Blood Mononuclear Cells Elizabeth Gan, Megan Stoker, Edie Guo, Karl J. Morten & Jiabao Xu [Line break added] Abstract A reliable, validated test would enhance our ability to treat and research chronic conditions. Early and...

Are you saying that the way their model works is, if, say, one DLGAP is very useful for the model classification, that makes it more likely for other DLGAP genes to also have high attention scores, even if potentially there isn't much difference between the cases and controls for the others?

The rankings in the Biobank data for chronic fatigue syndrome for these 115 genes might be interesting as well:

And in case anyone's curious about which of the 115 Zhang genes are most significant for depression, here are the 115 genes with their rankings out of the 18,358 total genes tested in depression. You can check here on the depression page, sort by P-Value SKATO, and verify that HOMER2 is the 44th...

I wanted to dig into that chart of phenotype associations (fig. 5: depression, COVID, etc). I realized the data they used is all on Genebass. I tried to figure out how to work with all >4500 phenotypes, but I couldn't figure out how to access the bulk data which is hosted in Google Cloud...

Two better answers than I could have given above, so hopefully that's sufficient.

Albuminuria and Mental Illness Risk: Results From National Health and Nutrition Examination Survey 2005–2018 and Mendelian Randomization Analyses Yangyang Wang, Sen Li [Line breaks added] Background Recent evidence suggests a link between albuminuria and mental illness. However, whether this...

Full paper now published: HIV Infection and Long COVID: A RECOVER Program, Electronic Health Record Based Cohort Study Kellie L Hawkins, Dima Dandachi, Zoe Verzani, M Daniel Brannock, Colby Lewis, Sajjad Abedian, Sohrab Jaferian, Shannon Wuller, Jennifer Truong, Margot Gage Witvliet, Gretchen...

Recent article about ubrogepant for migraine prodromal symptoms (link to thread): Ubrogepant for the treatment of migraine prodromal symptoms: an exploratory analysis from the randomized phase 3 PRODROME trial (2025, Nature Medicine)

Nature News: 'Migraine drug is first to tackle debilitating early symptoms' [Paywall] "Scientists have shown that a drug approved to treat migraine headaches can also alleviate debilitating non-headache symptoms, such as fatigue, brain fog and blinding light sensitivity, that occur as the...

Ubrogepant for the treatment of migraine prodromal symptoms: an exploratory analysis from the randomized phase 3 PRODROME trial Peter J. Goadsby, Jessica Ailani, David W. Dodick, Amaal J. Starling, Chengcheng Liu, Yingyi Liu, Sung Yun Yu, Jonathan H. Smith, Elimor Brand-Schieber & Joel M...

Thanks yeah, missed it the first time. So I don't think the decrease in HHV6 is very meaningful here without a long COVID control group. Their patient group might just select for people who had a temporary flare-up of the virus and at the follow-up they were back to normal - regression to the...

Hmm, yeah maybe. They didn't make it clear enough in the full text if that is the case. Edit: Ah actually, it seems they do say they confirm the patients were positive to be included:

I don't see any indication in the text that that's the case:

Screenshot from the Berlin ME/CFS Conference that happened a couple days ago: Transcription of Dr. Mella describing this:

With the synapse-related findings, it might be worth revisiting this other GWAS that found a nervous system related gene: Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci (Hajdarevic et al, 2022, Brain, Behavior, and...

Low-Dose Naltrexone for Severe Fibromyalgia Syndrome: A Report of a Case With Two-Year Follow-Up Ulrich Moser [Line breaks added] Abstract Fibromyalgia syndrome (FMS) is characterized by diffuse musculoskeletal pain associated with daytime fatigue, sleep disturbance, cognitive deficits, and...

Well the replication set was only composed of the Cornell cohort. But maybe it's something to consider with regard to some of the specific genes picked out using the two cohorts that made up the discovery set.