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  1. boolybooly
    Post

    Patients with ME/CFS and chronic pain report similar level of sickness behavior as individuals injected with bacterial endotoxin... 2019, Jonsjö et al

    I was willing to give them the benefit of the doubt except for the following passage as mentioned above, because they do not consider...
    Post by: boolybooly, Jan 12, 2020 in forum: ME/CFS research
  2. boolybooly
    Post

    Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (2019) Karhan, Unutmaz et al

    Bearing in mind this needs replication to be worthy of treating as fact, my preliminary comment would be the observed impairment of Th17 and MAIT...
    Post by: boolybooly, Jan 6, 2020 in forum: ME/CFS research
  3. boolybooly
    Post

    Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test, 2019, Morten, Newton et al

    I agree its pretty anecdotal and subjective. I am prepared to believe different people respond differently. For some it seems to be much more...
    Post by: boolybooly, Dec 28, 2019 in forum: ME/CFS research
  4. boolybooly
    Post

    Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test, 2019, Morten, Newton et al

    I am one of Dr Myhill's patients and I think it makes more sense if you remember she sees a lot of CFS of various causes including organophosphate...
    Post by: boolybooly, Dec 28, 2019 in forum: ME/CFS research
  5. boolybooly
    Post

    The Impact of a Structured Exercise Programme upon Cognitive Function in Chronic Fatigue Syndrome Patients, 2019, Zalewski, Morten, Newton et al

    I couldnt agree more.
    Post by: boolybooly, Dec 22, 2019 in forum: Psychosomatic research - ME/CFS and Long Covid
  6. boolybooly
    Post

    ME/CFS as a hyper-regulated immune system driven by an interplay between regulatory T cells & chronic human herpesvirus infections (2019) Nacul et al.

    OK working my way through this, a few things worth mentioning to help other people get into it. B cells are from Bone and T cells are from...
    Post by: boolybooly, Nov 23, 2019 in forum: ME/CFS research
  7. boolybooly
    Post

    A logistic regression analysis of risk factors in ME/CFS pathogenesis. Lacerda et al. 2019

    Another thing to be careful of is the old association vs causation error. The association of virus episodes prior to ME onset might be seen as...
    Post by: boolybooly, Nov 10, 2019 in forum: ME/CFS research
  8. boolybooly
    Post

    ME/CFS as a hyper-regulated immune system driven by an interplay between regulatory T cells & chronic human herpesvirus infections (2019) Nacul et al.

    They must be aware of the Rituximab results, agree will be interested to see what the full paper is saying. I am just "delighted" they are...
    Post by: boolybooly, Nov 6, 2019 in forum: ME/CFS research
  9. boolybooly
    Post

    ME/CFS as a hyper-regulated immune system driven by an interplay between regulatory T cells & chronic human herpesvirus infections (2019) Nacul et al.

    I am, that fits my CFIDS symptoms to a tee.
    Post by: boolybooly, Nov 5, 2019 in forum: ME/CFS research
  10. boolybooly
    Post

    ME/CFS as a hyper-regulated immune system driven by an interplay between regulatory T cells & chronic human herpesvirus infections (2019) Nacul et al.

    Interesting, this appears to be more specifically about what I have which is comforting to see. Makes me glad I backed the LSHTM biobank. ME...
    Post by: boolybooly, Nov 5, 2019 in forum: ME/CFS research
  11. boolybooly
    Post

    Is ME a metabolic problem or a signalling problem?

    On that last question, yes bicarb definitely makes air hunger worse for me but helps carby burn. Dr Cheney thinks the body has a natural response...
    Post by: boolybooly, Oct 21, 2019 in forum: ME/CFS research news
  12. boolybooly
    Post

    Is ME a metabolic problem or a signalling problem?

    I dont know about these specific studies but it raises an increasingly important and politically relelvant issue regarding the nature of ME as a...
    Post by: boolybooly, Oct 21, 2019 in forum: ME/CFS research news
  13. boolybooly
    Post

    Is ME a metabolic problem or a signalling problem?

    I am not sure how this theory matches/meshes with with Dr Cheney's clinical observations. From personal experience I found about a decade ago...
    Post by: boolybooly, Oct 21, 2019 in forum: ME/CFS research news
  14. boolybooly
    Post

    Is ME a metabolic problem or a signalling problem?

    FYI in case it is relevant, Dr Paul Cheney theorised that PWME had intracellular acidosis and extracellular alkalosis causing difficulties with...
    Post by: boolybooly, Oct 16, 2019 in forum: ME/CFS research news
  15. boolybooly
    Post

    Food tastes too sweet?

    https://www.healthline.com/health/sweet-taste-in-mouth#causes It could be a bug. I remember you made a post about having severe multiple...
    Post by: boolybooly, Oct 13, 2019 in forum: General and other signs and symptoms
  16. boolybooly
    Post

    Comparison of Diagnostic Criteria - discussion thread

    IMHO the biggest problem with all the criteria is they do not consider TH2 shifting. i.e. raised allergic tendency. The problem is most of the...
    Post by: boolybooly, Oct 5, 2019 in forum: Diagnostic Criteria and Naming Discussions
  17. boolybooly
    Post

    Is ME a metabolic problem or a signalling problem?

    Interesting question. Strikes me there is no knowing at this juncture. From my own experience and others' reports, people often experience...
    Post by: boolybooly, Oct 1, 2019 in forum: ME/CFS research news
  18. boolybooly
    Post

    An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients Missailidis et al. 2019

    Seahorse, summary of inconsistent results in previous studies....
    Post by: boolybooly, Sep 11, 2019 in forum: ME/CFS research
  19. boolybooly
    Post

    Is ME a metabolic problem or a signalling problem?

    Both is the right answer IMHO since you ask. What you have to bear in mind @Trish is that most disease symptoms are caused by the immune response...
    Post by: boolybooly, Sep 3, 2019 in forum: ME/CFS research news
  20. boolybooly
    Post

    Inflammatory proteins are altered in chronic fatigue syndrome – a systematic review and meta-analysis, 2019, Strawbridge et al

    No, yet ironic that non friends are talking about subgroups, which is where imho we all need to be heading. Call me cynical, but the devil is in...
    Post by: boolybooly, Sep 1, 2019 in forum: ME/CFS research
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