If immune tolerance is at play, odds are nothing would.
Could still be a downstream effect of a virus, just not a flare per se. Acquired channelopathies come to mind (just as an example).
I'm pretty sure we discussed it here. Sorry, my brain can't work the Search function.
It could be a lot of things. My vague recollection is he found NO evidence of ANY pathogen - virus, bacteria, or parasite - in ANY OF HIS COHORT...
I believe this may apply to me as well. Not clear if it's viral, though. Overall though, in terms of persistence, the more I dig into immune...
I recall it well. I was not impressed then either.
If the diagnostic is questionable - and far too many actually are - its significance would be limited. This also holds true for reactivation metrics.
I'm not sure how meaningful this is. Put another way, this is about as meaningful as claiming there is pretty good negative evidence for...
Thank you, @Hutan. Although the study technically concerns Lyme, it's the scanning technique, and the purported brain inflammation it suggests,...
The suggested neuroinflammation was what I found intriguing - and how that could translate in ME/CFS TSPO imaging efforts (reminiscent of Nakatomi...
Another PET TSPO neuroimaging study suggesting neuroinflammation involving microglia, this time in PTLDS:...
No. In most cases, it is not.
Or if your immune system is fooled, e.g., antigenic variation.
Shameful.
Surprise.
How do you define a reactivated infection?
The conventional model, e.g. CDC's, for ME/CFS is exclusionary: You cannot have any infection that can cause ME/CFS symptoms. So, does testing...
Could it be the quality of the diagnostics? Ok, yes, I can see that. That makes sense. But this is where I need help. So our symptoms...
As far as I can tell, any theory would have to account for: A myriad of fluctuating symptoms that can be broadly inconsistent among the patient...
I'd be interested in a very focused look into acquired immune tolerance and how it may relate to pwME. I'm not quite clear on a few things, not...
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